• Specification

    Product Description

    Made to order FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. ().

    Origin

    Human

    Source

    Genomic DNA

    Reactivity

    Human

    Notice

    We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.

    Regulation Status

    For research use only (RUO)

    Supplied Product

    DAPI Counterstain (1500 ng/mL ) 250 uL

    Storage Instruction

    Store at 4°C in the dark.

  • Applications

    Fluorescent In Situ Hybridization (Cell)

    Protocol Download
  • Gene Info — CTSB

    Entrez GeneID

    1508

    Gene Name

    CTSB

    Gene Alias

    APPS, CPSB

    Gene Description

    cathepsin B

    Omim ID

    116810

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq

    Other Designations

    APP secretase|OTTHUMP00000116009|amyloid precursor protein secretase|cathepsin B1|cysteine protease|preprocathepsin B

  • Interactome
  • Pathway
  • Disease

    + View More Disease

    - View Less Disease