I-BET 151 hydrochloride [1883545-47-8]
Cat# B5670-10mg
Size : 10mg
Marca : APExBIO Technology
I-BET 151 dihydrochloride is a bET bromodomain inhibitor that prevents BET from recruiting to chromatin. I-BET 151 induces MLL-fusion leukemia cell line apoptosis and G0 / G1 cell cycle arrest in vitro, and reduces BCL2 expression in NOMO1 cells. I-BET 151 improves the survival rate of two kinds of MLL fusion leukemia mice, and enhances the differentiation of human iPSCs into megakaryocytes.
Reference:
[1]. Malherbe P, Masciadri R, Norcross R D, et al. Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. British journal of pharmacology, 2008, 154(4): 797.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 451.9 |
| Cas No. | 1883545-47-8 |
| Formula | C23H21N5O3·HCl |
| Solubility | insoluble in H2O; ≥22.05 mg/mL in EtOH; ≥31.7 mg/mL in DMSO |
| Chemical Name | 7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2-ol hydrochloride |
| Canonical SMILES | C[C@H](c1ncccc1)71c(O)nc2c1c(cc(c(-c1c(C)2026nc1C)c1)OC)c1nc2.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
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