LCS-1 [41931-13-9]
Cat# HY-115445-10mg
Size : 10mg
Marca : MedChemExpress
LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibits SOD1 activity with an IC50 value of 1.07 μM. LCS-1 induces the early- and late-stage apoptosis of multiple myeloma (MM.1S) cells.
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LCS-1 Chemical Structure
CAS No. : 41931-13-9
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Description |
LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibits SOD1 activity with an IC50 value of 1.07 μM. LCS-1 induces the early- and late-stage apoptosis of multiple myeloma (MM.1S) cells[1][2][3]. |
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IC50 & Target[2] |
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In Vitro |
LCS-1 (1-10000 nM; 24 hours) has selective cytotoxicity towards bloom syndrome gene product (BLM) -proficient and BLM-deficient HCT116 cells[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
Western Blot Analysis[3]
Western Blot Analysis[3]
Western Blot Analysis[3]
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In Vivo |
LCS-1 (20 mg/kg; i.p. every other day for 14 days) inhibits MM growth and prolongs host survival in MM.1S-bearing mice[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Masse moléculaire |
255.10 |
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Formule |
C11H8Cl2N2O |
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CAS No. |
41931-13-9 |
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Appearance |
Solid |
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Color |
Light yellow to light brown |
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SMILES |
O=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(C)=C2 |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : 50 mg/mL (196.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation |
Purity: 99.59% |
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Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 3.9200 mL | 19.6002 mL | 39.2003 mL | 98.0008 mL |
5 mM | 0.7840 mL | 3.9200 mL | 7.8401 mL | 19.6002 mL | |
10 mM | 0.3920 mL | 1.9600 mL | 3.9200 mL | 9.8001 mL | |
15 mM | 0.2613 mL | 1.3067 mL | 2.6134 mL | 6.5334 mL | |
20 mM | 0.1960 mL | 0.9800 mL | 1.9600 mL | 4.9000 mL | |
25 mM | 0.1568 mL | 0.7840 mL | 1.5680 mL | 3.9200 mL | |
30 mM | 0.1307 mL | 0.6533 mL | 1.3067 mL | 3.2667 mL | |
40 mM | 0.0980 mL | 0.4900 mL | 0.9800 mL | 2.4500 mL | |
50 mM | 0.0784 mL | 0.3920 mL | 0.7840 mL | 1.9600 mL | |
60 mM | 0.0653 mL | 0.3267 mL | 0.6533 mL | 1.6333 mL | |
80 mM | 0.0490 mL | 0.2450 mL | 0.4900 mL | 1.2250 mL | |
100 mM | 0.0392 mL | 0.1960 mL | 0.3920 mL | 0.9800 mL |