Size : 10mg
Synonyms:
| Description | TGF-β2-IN-1 is a selective inhibitor of TGF-β2. It exhibits potent antiproliferative effects on HCT-116, Caco-2, and HT-29 cells, with IC50 values of 6.84, 10.21, and 9.47 μM, respectively. TGF-β2-IN-1 inhibits TGF-β2 signaling in a dose-dependent manner by suppressing receptor and cytokine expression. This compound is useful for colorectal cancer research. |
| In vitro | TGF-β2-IN-1 (Compound 10k) exhibits potent antiproliferative effects on HCT-116 (IC50 = 6.84 μM), Caco-2 (IC50 = 10.21 μM), and HT-29 (IC50 = 9.47 μM) at concentrations of 1.562-100 μM over 48 hours. It progressively reduces TGF-β2 receptor and cytokine levels in HCT-116 cells within the same concentration and time frame. At 50-100 μM for 48 hours, it does not significantly induce apoptosis or necrosis in HCT-116 cells. The compound demonstrates strong binding affinity to the TGF-β receptor II with an IFD XP Glide score of 11.28 kcal/mol. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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