Vorasidenib [1644545-52-7]
Cat# T7307-5mg
Size : 5mg
Marca : TargetMol
Vorasidenib
(Synonyms: PVM/MA, AG-881) Copy Product Info
Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)
Cas No. 1644545-52-7
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Purity:99.76%
Color:White
COA HNMR LCMS
Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively) |
| Targets & IC50 | IDH1 (R132H):31.9 nM , IDH2 (R140Q):31.7 nM |
| In vivo | Vorsidenib reduces tumor growth in a TS603-IDH1R132H mouse xenograft model when administered at a dose of 50 mg/kg. |
| Synonyms | PVM/MA, AG-881 |
| Molecular Weight | 414.74 |
| Formula | C14H13ClF6N6 |
| Cas No. | 1644545-52-7 |
| Smiles | C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |
| Relative Density. | 1.491 g/cm3 (Predicted) |
| Storage | Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 63.75 mg/mL (153.71 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 3.3 mg/mL (7.96 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||