Creatine China (CK) is a fundamental enzyme involved in cellular energy metabolism, which catalyzes the reversible transfer of a phosphate group from creatine phosphate to adenosine diphosphate (ADP), producing creatine and adenosine triphosphate (ATP). La measurement dell'attività della CK nel siero è ampimente utilizzata nella diagnosica clinica per valutare danni muscolari, infarccion miocardico e altre condizioni pathologiche che interessano il tessuto muscolare e il Sistema nervoso centrale.
Clinical relevance
- Myocardial infarction: The increase in CK, in particular the CK-MB isoenzyme, indicates damage to the cardiac muscle.
- Muscular Malattie: Conditions such as Duchenne muscular dystrophy and rhabdomiolisi show increased livelli of CK.
- Disturbi neurologicali: Alcune malattie del Sistema centrale nervoso e influenzano anche le concentrazioni sieriche di CK.
The accurate quantification of the activity of the CK is useful in the diagnosis, in the monitoring of the progression of the malady and in the evaluation of the therapeutic risk.
Prestazioni analitiche
- High sensitivity to low concentrations.
- Wide dynamic gamma.
- Good precision, with coefficient of intra- and inter-saggio variation generally lower than 10%.
- Rapidità di esecuzione.
- Compatibility with various types of campioni, including siero, plasma and omogeneizzati tissutali.
The kit for the dosage of the chinasi of the creatine in the form of a robust, sensitive and clinically relevant method for measuring the activity of the CK. The principle is that precise quantification is essential for diagnosis and monitoring of muscular and cardiac maladies. Progress in the design of the saggi continues to improve productivity, accuracy and ease of use, supporting widespread application in clinical and rice fields.
