Kirre Like Nephrin Family Adhesion Molecule 3 is encoded by the gene KIRREL3. KIRREL3 is a member of the immunoglobulin superfamily, nephrin-like protein family. KIRREL3 is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. KIRREL3 is expressed in brain, bone marrow, and stromal cells. Diseases associated with KIRREL3 include Autosomal Dominant Non-Syndromic Intellectual Disability and Autosomal Dominant Non-Syndromic Intellectual Disability 4.
Purified by Protein A chromatography
Lot dependent: provided at 0.3-0.5 mg/mL
Monoclonal
N321C/49
IgG2b
ICC
Mouse
Kirrel3 Kirrel3_predicted
85-105 kDa (multiple isoforms)
Fusion protein amino acids 46-524 (extracellular N-terminus) of rat Kirrel3 (accession number Q09GS6) produced recombinantly in E. Coli
Rat
Mouse, Rat
AB_2940150
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL594 Ex: 594 nm, Em: 615 nm
Reacts with Kirrel3 short and long isoformsDoes not cross-react with Kirrel1 and Kirrel2
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
