Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

Aucubin [479-98-1]

Stampa

Cat# NB-64-22034-100mg

Size : 100mg

Marca : Neo Biotech

Richiedere ulteriori informazioni

Aucubin (Synonyms: Rhinanthin, Aucuboside)

Catalog No. T3416 Copy Product Info

Purity: 99.83%

Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.

Aucubin

Copy Product Info

Synonyms Rhinanthin, Aucuboside

Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.

Cas No. 479-98-1

Batch Information

Select Batch

Purity:99.83%

Color:White to Red

Resource Download

COA

Product Introduction

Aucubin AI Summary

Aucubin exhibits a range of bioactivities, including inhibiting the classical complement pathway activation at 4 µM with significantly higher inhibition (89.3%) in the presence of beta glucosidase. It demonstrates potent inhibition of L3MBTL1 (63.1 nM) and induces DNA re-replication (183.6 nM) in SW480 colon adenocarcinoma cells. The compound also shows estrogenic activity at the ERalpha in human MVLN cells with activities of 81.25% and 99.1% at concentrations of 100 µg/mL and 20 µg/mL, respectively, compared to E2. It inhibits electric eel Acetylcholinesterase (AChE) and horse Butyrylcholinesterase (BChE) at 2 mg/mL, although the inhibition percentages are modest (-1.28% for AChE and -12.67% for BChE). Additionally, it exhibits moderate to high inhibitory activity against the COX1 enzyme (48.2% to 50.2%) but weaker activity against the COX2 enzyme (below 30%). It shows no significant cytotoxicity against various human cancer cell lines (IC50 > 10000 nM) and demonstrates minimal inhibitory effects against SARS-CoV-2 3CL-Pro protease (0.17% at 20 µM). Lastly, it exhibits 0.14% inhibition of SARS-CoV-2-induced cytotoxicity in VERO-6 cells at 10 µM concentration after 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
Synonyms	Rhinanthin, Aucuboside

Chemical Properties

Molecular Weight	346.33
Formula	C₁₅H₂₂O₉
Cas No.	479-98-1
Smiles	OCC1OC(OC2OC=CC3C(O)C=C(CO)C23)C(O)C(O)C1O
Relative Density.	1.61 g/cm3

Storage & Solubility Information

Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: 0.12 mg/mL (0.35 mM), Sonication is recommended H2O: Insoluble
In Vivo Formulation	10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.77 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.