Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

Coixol [532-91-2]

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Cat# NB-64-18973-100mg

Size : 100mg

Marca : Neo Biotech

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Coixol

(Synonyms: MBOA, 6-methoxybenzoxazolone, 6-Methoxy-2-benzoxazolinone, 6-MBOA) Copy Product Info

Synonyms: MBOA, 6-methoxybenzoxazolone, 6-Methoxy-2-benzoxazolinone, 6-MBOA

Catalog No. T2S2108 Copy Product Info

Purity: 99.98%

1. Coixol (MBOA) acts as a central muscle relaxant with an anti-convulsant effect. 2. Coixol interacts with the pituitary to stimulate reproduction in voles. 3. Coixol has the ability to interact with FSH to stimulate follicular development and increase ovulation. 4. Coixol can regulate gene expression, production and secretion of mucin, by directly acting on airway epithelial cells.

Cas No. 532-91-2

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:White to Orange

Product Introduction

Coixol AI Summary

Coixol exhibits multiple bioactivities, including significant anti-inflammatory, antioxidant, cytoprotective, and insecticidal effects. In Wistar rat peritoneal mast cells, it inhibits IgE-induced histamine release by 40.0% and concanavalin A-induced histamine release by 47.3%, with an IC50 value of 1.0 x 10^-3 M for the latter. Additionally, it inhibits CuSO4-induced human LDL oxidation, prolonging the lag phase of conjugated diene formation, and provides cytoprotection against minimally oxidized LDL-induced cytotoxicity in BAEC, as indicated by 90.0% cell viability post-treatment. Furthermore, Coixol demonstrates insecticidal activity against Sitobion avenae apterous virginoparous nymphs, particularly at lower concentrations, with the most significant suppression of the insects' intrinsic reproduction rate observed at 0.1 mM concentration after 4 weeks of exposure..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Coixol (MBOA) acts as a central muscle relaxant with an anti-convulsant effect. 2. Coixol interacts with the pituitary to stimulate reproduction in voles. 3. Coixol has the ability to interact with FSH to stimulate follicular development and increase ovulation. 4. Coixol can regulate gene expression, production and secretion of mucin, by directly acting on airway epithelial cells.
Synonyms	MBOA, 6-methoxybenzoxazolone, 6-Methoxy-2-benzoxazolinone, 6-MBOA

Chemical Properties

Molecular Weight	165.15
Formula	C₈H₇NO₃
Cas No.	532-91-2
Smiles	COc1ccc2[nH]c(=O)oc2c1
Relative Density.	1.309g/cm3

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (302.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0551 mL	30.2755 mL	60.5510 mL	302.7551 mL
5 mM	1.2110 mL	6.0551 mL	12.1102 mL	60.5510 mL
10 mM	0.6055 mL	3.0276 mL	6.0551 mL	30.2755 mL
20 mM	0.3028 mL	1.5138 mL	3.0276 mL	15.1378 mL
50 mM	0.1211 mL	0.6055 mL	1.2110 mL	6.0551 mL
100 mM	0.0606 mL	0.3028 mL	0.6055 mL	3.0276 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

polyphenolInhibitorinhibitCoixolcoixBacterialantitumorantimicrobial

Related Tags: Coixol chemical structure | Coixol formula | Coixol molecular weight