MSH6 Polyclonal Antibody
Cat# bs-55135R
Size : 100uL
Marca : Bioss
Lane 1: Hela cell lysates; Lane 2: MSH6 knockout (KO) HeLa cell lysates probed with MSH6 Polyclonal Antibody, Unconjugated (bs-55135R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.
Applications
Reactivity
| Overview | |
| Catalog # | bs-55135R |
| Product Name | MSH6 Polyclonal Antibody |
| Applications | WB, IHC, IF |
| Reactivity | Human, Mouse, Monkey |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human MSH6 (NP_000170.1). |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C for 12 months. |
| Target | |
| Gene ID | 2956 |
| Swiss Prot | P52701 |
| Subcellular location | Nucleus |
| Synonyms | MSH6;GTBP;GTMBP;HNPCC5;HSAP;p160 |
| Background | This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. |
| Application Dilution | |
| WB | 1:300-5000 |
| IHC | |
| IF | |