Prostaglandin E Receptor EP2 Positive Control peptide

Formulation:	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range:	WB: 1:500
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PTGER3
Gene ID:	5733
Uniprot ID:	PE2R3_HUMAN

Tissue Specificity	Detected in kidney. Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.
Function	Receptor for prostaglandin E2 (PGE2). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium. Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality.
Peptide Name	Prostaglandin E2 Receptor Ep3 Subtype Pge Receptor Ep3 Subtype Pge2 Receptor Ep3 Subtype Pge2-R Prostanoid Ep3 Receptor
Database Links	Reactome: R-HSA-391908 Reactome: R-HSA-418594
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Peptide Names	Prostaglandin E2 Receptor Ep3 Subtype protein Pge Receptor Ep3 Subtype protein Pge2 Receptor Ep3 Subtype protein Pge2-R protein Prostanoid Ep3 Receptor protein PTGER3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance