Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

RG2833 [1215493-56-3]

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Cat# T6639-5mg

Size : 5mg

Marca : TargetMol

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RG2833

(Synonyms: RGFP109) Copy Product Info

RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC₅₀ of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.

Cas No. 1215493-56-3

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:99.50%

Color:White

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COA LCMS HNMR

Product Information

Bioactivity

Description	RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC₅₀ of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
Targets & IC50	HDAC3:5 nM(Ki), HDAC1:32 nM(Ki), HDAC3:50 nM, HDAC1:60 nM
In vitro	In unstimulated peripheral blood mononuclear cells, RG2833 upregulates the level of the synaptic mRNA and protein in a dose-dependent manner.
Synonyms	RGFP109
Kinase Assay	Aconitase activities are determined by homogenization of mouse brain tissues on ice at 10% w/v in CellLytic MT Mammalian Tissue Lysis/Extraction buffer, followed by centrifugation at 800×g?for 10?min at 4°C. Tissue lysates (50?μL) are then added to 200?μL of substrate mix (50?mM Tris/HCl pH 7.4, 0.4?mM NADP, 5?mM Na citrate, 0.6?mM MgCl2, 0.1% (v/v) Triton X-100 and 1U isocitrate dehydrogenase) and the reactions are incubated at 37°C for 15?min, followed by spectrophotometric absorbance measurements every minute for 15?min at 340?nm 37°C to determine the reaction slope. Aconitase activities of mouse brain tissues are then normalized to citrate synthase activities, which are determined using a citrate synthase assay kit.

Chemical Properties

Molecular Weight	339.43
Formula	C₂₀H₂₅N₃O₂
Cas No.	1215493-56-3
Smiles	Cc1ccc(cc1)C(=O)NCCCCCC(=O)Nc1ccccc1N
Relative Density.	1.163 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (368.26 mM), Sonication is recommended.

Ethanol: 10 mg/mL (29.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.89 mM), Sonication is recommended.

10% DMSO+90% Saline: 10 mg/mL (29.46 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9461 mL	14.7306 mL	29.4612 mL	147.3058 mL
5 mM	0.5892 mL	2.9461 mL	5.8922 mL	29.4612 mL
10 mM	0.2946 mL	1.4731 mL	2.9461 mL	14.7306 mL
20 mM	0.1473 mL	0.7365 mL	1.4731 mL	7.3653 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0589 mL	0.2946 mL	0.5892 mL	2.9461 mL
100 mM	0.0295 mL	0.1473 mL	0.2946 mL	1.4731 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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