For anti-ZFP36 (ARP38303_P050) antibody is Catalog # AAP38303 (Previous Catalog # AAPP10115)
Reference
Cao,H., et al., (2006) Biochem. J. 394 (PT 1), 285-297
Publications
Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. Biomolecules. 5, 2035-55 (2015). 26343742
Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy. Cell Mol Gastroenterol Hepatol. 11, 597-621 (2020). 32987153
ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
8
Biological process
Name
# of Products
3-UTR-mediated mRNA stabilization
12
Gene expression
503
Intracellular protein kinase cascade
91
MRNA catabolic process
16
MRNA metabolic process
178
Negative regulation of inflammatory response
54
Negative regulation of myeloid cell differentiation
9
Negative regulation of transcription from RNA polymerase II promoter
574
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
2
Regulation of mRNA stability
13
Regulation of tumor necrosis factor production
2
Response to stress
160
RNA destabilization
2
RNA metabolic process
206
Cellular components
Name
# of Products
Cytoplasm
4549
Cytoplasmic stress granule
17
Cytosol
1868
Nucleus
4914
Protein function
Name
# of Products
14-3-3 protein binding
24
AU-rich element binding
32
C-C chemokine binding
15
DNA binding
3958
Metal ion binding
5514
MRNA binding
118
Protein binding
12191
Protein kinase binding
1101
Single-stranded RNA binding
61
Zinc ion binding
3721
What is the species homology for "ZFP36 Antibody - N-terminal region (ARP38303_P050)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".
How long will it take to receive "ZFP36 Antibody - N-terminal region (ARP38303_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
What buffer format is "ZFP36 Antibody - N-terminal region (ARP38303_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.". Additional format options may be available. For more information please contact info@avivasysbio.com.
What are other names for "ZFP36 Antibody - N-terminal region (ARP38303_P050)"?
This target may also be called "TTP, G0S24, GOS24, TIS11, NUP475, zfp-36, RNF162A" in publications.
What is the shipping cost for "ZFP36 Antibody - N-terminal region (ARP38303_P050)"?
The shipping cost for this item is within the US. Please contact us for specific shipping for international orders.
What is the guarantee for "ZFP36 Antibody - N-terminal region (ARP38303_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
Can I get bulk pricing for "ZFP36 Antibody - N-terminal region (ARP38303_P050)"?
You can get bulk pricing for this item by going here.
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "34kDa". Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.
What protocols are available for "ZFP36 Antibody - N-terminal region (ARP38303_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
What are positive controls for "ZFP36"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
What are negative controls for "ZFP36"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
What other proteins interact with "ZFP36"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
What biological processes are associated with "ZFP36"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
What cellular components are associated with "ZFP36"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
What protein functions are associated with "ZFP36"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
ELISA Titer: 1:312500 Positive Control: Human Lung" data-size="300x300" class="product-image-wrapper cover">
ZFP36 Antibody - middle region (ARP38304_P050)
Catalog #: ARP38304_P050
Species Tested: Human
Application: IHC, WB
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ZFP36 Antibody - N-terminal region (ARP34386_P050)
Catalog #: ARP34386_P050
Species Tested: Human
Application: IHC, WB
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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