Human Mannose Phosphate Isomerase (MPI) activation kit by CRISPRa

CAT#: GA102961

MPI CRISPRa kit - CRISPR gene activation of human mannose phosphate isomerase



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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol MPI
Locus ID 4351
Kit Components

GA102961G1, Mannose Phosphate Isomerase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102961G2, Mannose Phosphate Isomerase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102961G3, Mannose Phosphate Isomerase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001289155, NM_001289156, NM_001289157, NM_002435, NM_001330372
UniProt ID P34949
Synonyms CDG1B; PMI; PMI1
Summary Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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