Creative Biogene

Category

Service

Description

  Gene Editing   

  Precision Genome Engineering  

  Leveraging CRISPR-Cas9 and base editing technologies for customized services in gene knockout, knock-in, and point mutations across mammalian cells, plants, and industrial microbes. HIEF™ platform enables rapid stable cell line generation for antibody drug development, CAR-T/NK cell therapies, and recombinant protein production.  

  Viral Vector Solutions  

  Specializing in high-titer viral vector production (AAV, lentivirus, adenovirus) for gene therapy and vaccine development. Key offerings include tissue-specific AAV serotypes, oncolytic viruses, and GMP-grade lentiviral vectors for clinical trials.   

  RNA Technology   

  RNA Synthesis & Delivery  

  Supports full-spectrum nucleic acid drug development, including mRNA/circRNA design, chemical modifications (e.g., GalNAc conjugation, 5’-capping), and advanced delivery systems (lipid nanoparticles, exosomes, polymer-based carriers). Includes siRNA therapeutics, self-amplifying RNA vaccines, and RNA-based gene editing tools.  

  Functional & Mechanistic Studies  

  RNA-seq, single-cell sequencing, and spatial transcriptomics services for deep insights into gene regulation, with shRNA/miRNA libraries to facilitate high-throughput target validation.  

  Microbial Engineering   

  Strain Development & Fermentation  

  Engineering high-performance microbial strains (E. coli, Bacillus, Streptomyces) for enzyme production, recombinant biologics, and next-generation probiotics, with scalable fermentation from bench-scale to 1kL bioreactors.  

  cGMP Compliance  

  Services include 16S/ITS sequencing, MALDI-TOF MS-based identification, endotoxin testing, and stability studies, ensuring regulatory compliance for industrial and pharmaceutical applications.  

 Preclinical Development 

 Target-based Drug Screening 

 Screening and profiling across hot drug targets including GPCRs, ion channels, kinases, phosphatases, Nuclear receptors, Proteases, E3s, DUBs, Methyltransferase, Demethylase, etc. 

 In Vivo/In Vitro Models 

 PDX/PDO tumor models, zebrafish toxicity platforms (cardio/hepatic/renal assessments), and metabolic disease models (NAFLD, diabetes) to accelerate efficacy and safety profiling. 

ADME-Tox & Pharmacokinetics

Integrated services include CYP450 phenotyping, PAMPA permeability assays, plasma protein binding studies, and in vivo PK/PD modeling to support IND-enabling workflows.