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> (±)-α-Bisabolol [515-69-5]

(±)-α-Bisabolol [515-69-5]

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Referentie orb1685417-10g

Formaat : 10g

Merk : Biorbyt


(±)-α-Bisabolol

SKU: orb1685417

Description

(±)-α-Bisabolol is a natural sesquiterpene alcohol with documented anti-inflammatory, antioxidant, and anticancer properties. Research indicates it induces apoptosis and cell cycle arrest in vitro, such as in A549 lung cancer cells (IC50 = 15 µM) and glioma models, by targeting mitochondrial function and PI3K/Akt signaling pathways.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Images & Validation

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(±)-α-Bisabolol

Key Properties

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CAS Number515-69-5
MW222.37
Purity99.44% (May vary between batches)
FormulaC15H26O
SMILESCC(C)=CCCC(C)(O)C1CCC(C)=CC1
TargetApoptosis|||Antioxidant
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (14.84 mM);DMSO:90 mg/mL (404.73 mM)

Bioactivity

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Target IC50
PI3K/Akt:15 μM
In Vivo
(-)-α-Bisabolol (100-200 mg/kg; p.o.; one day before and 1 h after pMCAO; once daily for the following five days; mice) significantly reduces the infarcted area and neurological deficits caused by pMCAO. (−)-α-bisabolol can exert anti-inflammatory effects by reducing astrogliosis, MPO activity, and TNF-α and iNOS production. (–)-a-bisabolol attenuated the increased responses of carbachol in tracheal rings of ovalbumin-sensitized rats challenged with ovalbumin, but was without effect in the decreased responsiveness of urinary bladder strips in mice treated with ifosfamide. (–)-a-bisabolol may be an inhibitor of voltage-dependent Ca2+ channels.
In Vitro
Under resting tonus, (–)-a-bisabolol (30–300 µmol/L) relaxed duodenal strips. Contracting endothelium-intact aortic rings and urinary bladder strips, and relaxing these tissues at higher concentrations (600–1000 µmol/L). In preparations precontracted either electromechanically (by 60 mmol/L K+) or pharmacomechanically (by phenylephrine or carbachol), (–)-a-bisabolol showed only relaxing properties.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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alpha-Bisabolol, a-Bisabolol, Antioxidant, Apoptosis, Bisabolol, Calcium Channel, α-Bisabolol
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  • Levomenol [orb1685377]

    95.00% (May vary between batches)

    23089-26-1

    222.37

    C15H26O

    100 mg, 1 ml x 10 mM (in DMSO)

Compound Identifiers

PubChem CID
10586 ↗

Key Properties

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Protocol Information

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