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(-)-α-Terpineol [10482-56-1]

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Referentie NB-64-41651-1mL

Formaat : 1mLx10mM(inDMSO)

Merk : Neo Biotech

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(-)-α-Terpineol

(Synonyms: α-Terpineol) Copy Product Info

Synonyms: α-Terpineol

Catalog No. T7468 Copy Product Info

Purity: 99.85%

(-)-α-Terpineol has antitumour, anti-inflammatory, and antimicrobial activities, it inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway

Cas No. 10482-56-1

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.85%

Appearance:Solid

Color:White

Product Introduction

(-)-α-Terpineol AI Summary

(-)-α-Terpineol exhibits a variety of biological activities across different systems. It has cicatrizant activity in mice, showing wound healing properties with an effective dose (ED50) of 240.0 mg/kg as measured by tensile strength. Additionally, it inhibits growth of mouse 3T3 cells with a GI50 of 17.0 ug/mL. It has antioxidant properties, with a DPPH radical scavenging EC50 value of 146.3 ug/mL, indicating its potential to neutralize free radicals. The compound demonstrates antimicrobial activity against a range of microorganisms, including Propionibacterium acnes, Streptococcus mutans, and Pityrosporum ovale, with MICs of 100.0, 400.0, and 400.0 ug/mL, respectively, as well as antifungal activity against Aspergillus flavus with complete inhibition at 60 uL and 20 uL concentrations. In terms of acaricidal activity, (-)-α-Terpineol is highly effective against Psoroptes cuniculi, exhibiting activity levels from 73.3% to 100.0% in various assays. It also shows insecticidal capabilities against Leptinotarsa decemlineata (Colorado potato beetle) and Musca domestica (house fly), with varying mortality rates and an LD50 of 137.5 ug for house flies. Furthermore, it exhibits anti-mite activity against Tetranychus urticae with LC50 values ranging from 36.1 to 44.2 microg/cm3. In specific enzymatic assays, (-)-α-Terpineol shows activity related to UGT1A4 but not UGT1A1, with an activity rate of 25.0 pm/min/mg. It also possesses a log K value of 0.82, suggesting a balance between hydrophobic and hydrophilic properties. This broad-spectrum bioactivity makes (-)-α-Terpineol a compound of interest for multiple applications including wound healing, antioxidation, antimicrobial, acaricidal, and insecticidal potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(-)-α-Terpineol has antitumour, anti-inflammatory, and antimicrobial activities, it inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway
Synonyms	α-Terpineol

Chemical Properties

Molecular Weight	154.25
Formula	C₁₀H₁₈O
Cas No.	10482-56-1
Smiles	CC1=CC[C@H](CC1)C(C)(C)O
Relative Density.	0.93 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (145.87 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4830 mL	32.4149 mL	64.8298 mL	324.1491 mL
5 mM	1.2966 mL	6.4830 mL	12.9660 mL	64.8298 mL
10 mM	0.6483 mL	3.2415 mL	6.4830 mL	32.4149 mL
20 mM	0.3241 mL	1.6207 mL	3.2415 mL	16.2075 mL
50 mM	0.1297 mL	0.6483 mL	1.2966 mL	6.4830 mL
100 mM	0.0648 mL	0.3241 mL	0.6483 mL	3.2415 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

wineswhitemonoterpeneInhibitorinhibita-Terpineolaromaalpha-Terpineol()αTerpineol( ) α Terpineol

Related Tags: (-)-α-Terpineol chemical structure | (-)-α-Terpineol formula | (-)-α-Terpineol molecular weight