27-Hydroxycholesterol [20380-11-4]
Referentie TQ0274-5mg
Formaat : 5mg
Merk : TargetMol
27-Hydroxycholesterol
(Synonyms: 27-OHC, (25R)-26-Hydroxycholesterol) Copy Product Info
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
Cas No. 20380-11-4
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.82%
COA LCMS HNMR
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor. |
| In vitro | 27-Hydroxycholesterol activates estrogen receptors, adversely impacting prostate cancer cell lines by significantly enhancing cell proliferation in LNCaP and PC3 cells. This proliferation can be mitigated by estrogen receptor inhibitors [1]. As an endogenous selective estrogen receptor modulator, 27-Hydroxycholesterol exhibits substantial partial agonist activity across various cellular models, notably increasing gene transcription and cell proliferation in breast cancer contexts [2]. Produced from cholesterol by the enzyme CYP27A1, it plays a vital role in regulating intracellular cholesterol equilibrium. Its pro-tumorigenic effects can be diminished by either statins or directly inhibiting CYP27A1 [3]. Furthermore, 27-Hydroxycholesterol's conversion from cholesterol is crucial for LXR activation when faced with cholesterol excess [4]. |
| Synonyms | 27-OHC, (25R)-26-Hydroxycholesterol |
| Molecular Weight | 402.65 |
| Formula | C27H46O2 |
| Cas No. | 20380-11-4 |
| Smiles | 20[C@@]12CC[C@H]([C@H](C)CCC[C@@H](C)CO)[C@@]1(C)CC[C@@]1(20)[C@@]2(20)CC=C2C[C@@H](O)CC[C@]12C |
| Relative Density. | 1.03 |
| Storage | Keep away from direct sunlight,Store at low temperature,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF: 2 mg/mL (4.97 mM), Sonication is recommended. DMSO: 0.1 mg/mL (0.25 mM), Sonication is recommended. Ethanol: ≤ 20 mg/mL (49.66 mM), Sonication is recommended. |
| In Vivo Formulation | 10% EtOH+90% Corn Oil: 1 mg/mL (2.48 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. |