Reagentia en instrumenten voor immunologie, celbiologie en moleculaire biologie.

Ablukast [96566-25-5]

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Referentie T26519-5mg

Formaat : 5mg

Merk : TargetMol

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Ablukast

(Synonyms: Ro 23-3544) Copy Product Info

Ablukast (Ro 23-3544) is a leukotriene receptor antagonist that functions as an anti-asthmatic.

Cas No. 96566-25-5

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:98.58%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Ablukast AI Summary

Ablukast exhibits multiple pharmacological activities, including significant bioactivity as an antagonist against leukotriene D4 (LTD4) and leukotriene B4 (LTB4). It effectively inhibits LTD4-induced contraction in guinea pig trachea, displaying an IC50 value of 4000.0 nM and a Kd value of 251.19 nM. Additionally, it inhibits the binding of [3H]LTD4 to LTD4 receptors in guinea pig lung membranes and shows antagonistic activity with a Ki value of 320.0 nM against LTB4 binding on intact human neutrophils. Ablukast also demonstrates potency in blocking leukotriene-mediated bronchoconstriction via intravenous and aerosol administration, inhibiting arachidonic acid and antigen-induced bronchoconstriction in guinea pig models. Furthermore, it exhibits antiviral properties against SARS-CoV-2, with an IC50 value greater than 20000.0 nM in VERO-6 cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ablukast (Ro 23-3544) is a leukotriene receptor antagonist that functions as an anti-asthmatic.
Synonyms	Ro 23-3544

Chemical Properties

Molecular Weight	498.56
Formula	C₂₈H₃₄O₈
Cas No.	96566-25-5
Smiles	CCCc1c(O)c(ccc1OCCCCCOc1cc2OC(CCc2cc1C(C)=O)C(O)=O)C(C)=O
Relative Density.	1.219g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (120.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0058 mL	10.0289 mL	20.0578 mL	100.2888 mL
5 mM	0.4012 mL	2.0058 mL	4.0116 mL	20.0578 mL
10 mM	0.2006 mL	1.0029 mL	2.0058 mL	10.0289 mL
20 mM	0.1003 mL	0.5014 mL	1.0029 mL	5.0144 mL
50 mM	0.0401 mL	0.2006 mL	0.4012 mL	2.0058 mL
100 mM	0.0201 mL	0.1003 mL	0.2006 mL	1.0029 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.