| Short Description : | Rabbit polyclonal GABRA3 (29-276) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | |
| Gene ID: | |
| Uniprot ID: | |
| Immunogen Region: | 29-276 |
| Immunogen Sequence: | QGESRRQEPGDFVKQDIGGL SPKHAPDIPDDSTDNITIFT RILDRLLDGYDNRLRPGLGD AVTEVKTDIYVTSFGPVSDT DMEYTIDVFFRQTWHDERLK FDGPMKILPLNNLLASKIWT PDTFFHNGKKSVAHNMTTPN KLLRLVDNGTLLYTMRLTIH AECPMHLEDFPMDVHACPLK FGSYAYTTAEVVYSWTLGKN KSVEVAQDGSRLNQYDLLGH VVGTEIIRSSTGEYVVMTT |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-276 of human GABRA3 (NP_000799.1). |
| Function | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Alpha-3Gaba(A Receptor Subunit Alpha-3Gabaar Subunit Alpha-3 |
| Database Links | |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-3 antibodyAnti-Gaba(A Receptor Subunit Alpha-3 antibodyAnti-Gabaar Subunit Alpha-3 antibodyAnti-GABRA3 antibody |
Information sourced from Uniprot.org