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SKU DIA-700-P05 Specificity GFAP
Species Reactivity Human
Immunogen Fusion protein
Host Species Mouse
Isotype IgG1
Clone IF3
Clonality (Mono-/Polyclonal) monoclonal
Application Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections), Western Blot
Conjugation unconjugated
Dilution Histo-/Cytochemistry 1:300 – 1:600
Format 0.05% NaN3, 2% BSA, in PBS (pH 7.4), lyophilisate, purified antibody (from culture supernatant)
Product line / Topic Neurobiology, Tumor Marker / Biology
Intended Use for Research Use Only
Temperature - Storage 2-8°C
Temperature - Transport at room temperature
Search Code DIA700, FFPE, Paraffin
Manufacturer / Brand dianova
Uniprot_ID P14136
Gene_ID 2670
Alias GFAP, gfapl, Glial fibrillary acidic protein, Intermediate filament protein
- GFAP (Glial Fibrillary Acidic Protein) has proved to be the most specific marker for cells of astrocytic origin that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system. Monoclonal antibodies to GFAP are useful in differentiating primary gliomas from metastatic lesions in the brain and for documenting astrocytic differentia-tion in tumors outside the CNS.
As a 50 kDa intracytoplasmic filamentous protein, GFAP is thought to be important in astrocyte motility and shape by providing structural stability. As a consequence of injury to the human CNS caused by trauma, genetic disorders, or chemicals, GFAP is markly upregulated and astrocytes proliferate. On the other hand, with increasing astrocyte malignancy, a progressive loss of GFAP production has been observed. Consequntly, malignant astrocytomas have fewer tumour cells that stain positively and in-tensely for GFAP than do less malignant astrocytomas and normal brain specimens. Outside the CNS, GFAP has been demon-strated in Schwann cells, enteric glia cells, salivary gland neoplasms, and metastasizing renal carcinomas. Moreover, GFAP has been detected in epiglottic cartilage, pituicytes, immature oligodendrocytes, papillary meningiomas, and myoepithelial cells of the breast. -
Anti-GFAP (Hu) from Mouse (Clone: IF3)
Referentie DIA-700-P05
Formaat : 500µl
Merk : Dianova
Voor in vitro diagnostisch gebruik. Uitsluitend voor professioneel gebruik.