Apicidin
Referentie OOAU00081-5MG
Formaat : 5mg
Merk : Aviva Systems Biology
| Datasheets/Manuals | Printable datasheet for Apicidin (OOAU00081) |
|---|
| Product Format | White solid |
|---|---|
| Additional Information | Background: Potent inhibitor of histone deacetylase (HDAC) activity and proliferation. Induces cell cycle arrest at the G1 phase. At 100nM it induces a long lasting hyperacetylation of histone H4 while that induced by trichostatin is transient. Stimulates apoptosis. Apoptosis is induced via induction of Fas/Fas ligand. Displays potent antiangiogenic effects and dramatically decreases HIF-1a protein levels and transcriptional activity in human and mouse tumor cell lines. Apicidin is a fungal toxin that has broad spectrum activity against Apicomplexan parasites |
| :: | Features: Potent HDAC inhibitor. Blocks cell cycle progression at G1. Induces activation of HIV-1 promoter |
| :: | CAS Number: 183506-66-3 |
| :: | Chemical Formula: C34H49N5O6 |
| Reconstitution and Storage | RT |
| Alias Symbols | Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl] |
|---|---|
| Molecular Weight | 623.78 |