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Aspartame [22839-47-0]

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Referentie NB-64-00858-1g

Formaat : 1g

Merk : Neo Biotech

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Aspartame

(Synonyms: SC-18862) Copy Product Info

Synonyms: SC-18862

Catalog No. T0697 Copy Product Info

Purity: 99.71%

Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.

Cas No. 22839-47-0

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.71%

Appearance:Solid

Color:White

Product Information

Aspartame AI Summary

Aspartame exhibits a remarkably sweet potency, significantly higher than sucrose, with various quantifications ranging from a log SP of 2.11 to a sweet taste potency of 150.0 relative to sucrose. It is effective at a concentration of 750 p.p.m., showing no bitterness or other sensory properties and displaying high sweetness compared to sucrose. This compound shows diverse bioactivities including agonistic activity on the Thyroid Stimulating Hormone Receptor, inhibition of JMJD2A-Tudor Domain, anti-malarial and anti-viral activities against viruses like SARS-CoV-2, Marburg Virus, and Ebola Virus. It also demonstrates inhibition of the sodium fluorescein uptake in OATP1B1 and OATP1B3, a strong inhibitory effect on HBV and HCV, moderate inhibition of human SET7 enzyme activity, and weak inhibitory activity against human BSEP and HDAC6. pKa values of 3.19 and 7.87 highlight its potential interactions in variable pH environments. These properties underline the compound’s multifunctional bioactivity across different pathways and systems..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.
Synonyms	SC-18862

Chemical Properties

Molecular Weight	294.30
Formula	C₁₄H₁₈N₂O₅
Cas No.	22839-47-0
Smiles	[C@@H](CC1=CC=CC=C1)(NC([C@H](CC(O)=O)N)=O)C(OC)=O
Relative Density.	1.28 g/cm3
Sequence	H-Asp-Phe-OMe
Sequence Short	DF

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 4 mg/mL (13.59 mM), Sonication is recommended.

DMSO: 56 mg/mL (190.28 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3979 mL	16.9895 mL	33.9789 mL	169.8947 mL
5 mM	0.6796 mL	3.3979 mL	6.7958 mL	33.9789 mL
10 mM	0.3398 mL	1.6989 mL	3.3979 mL	16.9895 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1699 mL	0.8495 mL	1.6989 mL	8.4947 mL
50 mM	0.0680 mL	0.3398 mL	0.6796 mL	3.3979 mL
100 mM	0.0340 mL	0.1699 mL	0.3398 mL	1.6989 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Transient receptor potential cation channelTastereceptorTaste receptorsweetenerSC18862SC 18862phenylalaninenonnutritivemethylmethanolInhibitorinhibitesterdipeptideaspartic acidAspartame