Biotin-Linked Polyclonal Antibody to Mitogen Activated Protein Kinase 8 (MAPK8)

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]

JNK1: a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, pro-inflammatory cytokines and, in some instances, by growth factors and GPCR agonists. Substrates include a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2, thus regulating AP-1 transcriptional activity. In T- cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Activity increased in obesity. Inhibition or mouse knockout increases insulin sensitivity. Part of NFB pathway involved in inflammation and cancer, and signals downstream of Ras, though possibly as an apoptotic negative regulator of growth. Four alternatively-spliced isoforms have been described.

Protein type: CMGC group; EC 2.7.11.24; JNK subfamily; Kinase, protein; MAPK family; MAPK/JNK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 16p16

Cellular Component: axon; cytoplasm; cytosol; dendrite cytoplasm; intracellular; mitochondrion; nucleus; perikaryon; podosome; vesicle

Molecular Function: ATP binding; enzyme binding; histone deacetylase binding; histone deacetylase regulator activity; JUN kinase activity; kinase activity; kinesin binding; MAP kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: cellular response to amino acid starvation; cellular response to amyloid-beta; cellular response to cadmium ion; cellular response to hydrogen peroxide; cellular response to interleukin-1; cellular response to nitric oxide; cellular response to reactive oxygen species; dendrite morphogenesis; inflammatory response; JNK cascade; JUN phosphorylation; MAPK cascade; negative regulation of apoptosis; negative regulation of protein binding; neuron development; neuron migration; neuron projection development; ossification; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of apoptosis; positive regulation of apoptotic signaling pathway; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cell migration; positive regulation of cyclase activity; positive regulation of deacetylase activity; positive regulation of determination of dorsal identity; positive regulation of DNA replication; positive regulation of gene expression; positive regulation of microtubule polymerization; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of neuron migration; positive regulation of podosome assembly; positive regulation of protein metabolic process; programmed necrotic cell death; protein amino acid phosphorylation; protein localization to tricellular tight junction; regulation of centrosome cycle; regulation of circadian rhythm; regulation of DNA replication origin binding; regulation of gene expression; regulation of histone deacetylation; regulation of neuron differentiation; regulation of protein localization; regulation of transcription, DNA-templated; response to cadmium ion; response to heat; response to hydrogen peroxide; response to mechanical stimulus; response to osmotic stress; response to steroid hormone; response to UV; rhythmic process; signal transduction; stress-activated MAPK cascade