Bobcat339 [2280037-51-4]
Referentie T5198-50mg
Formaat : 50mg
Merk : TargetMol
Bobcat339
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Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
Cas No. 2280037-51-4
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.67%
Appearance:Solid
Color:White to Cyan
COA HNMR LCMS
Product Information
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Chemical Properties
Storage & Solubility Information
| Description | Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a. |
| Targets & IC50 | TET1:33 μM (cell free), TET2:73 μM (cell free) |
| In vitro | HT-22 cells were treated with 10 μM Bobcat339 in 1% DMSO for 24 hrs and lysed. Cells treated with Bobcat339 had significantly reduced global 5hmC levels as compared to vehicle control. |
| Molecular Weight | 297.74 |
| Formula | C16H12ClN3O |
| Cas No. | 2280037-51-4 |
| Smiles | Nc1nc(=O)n(cc1Cl)-c1cccc(c1)-c1ccccc1 |
| Relative Density. | 1.33 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11.59 mg/mL (38.93 mM), Sonication is recommended.  | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.72 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
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Keywords
TET2TET1epigeneticsDNMTsDNAMethyltransferaseDNA MTasesDNA methyltransferase (DNMT)DNA MethyltransferaseCytosine-based,TETBobcat-339Bobcat339Bobcat 339
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Related Tags: Bobcat339 chemical structure | Bobcat339 in vitro | Bobcat339 formula | Bobcat339 molecular weight