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Carprofen [53716-49-7]

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Referentie NB-64-04803-500mg

Formaat : 500mg

Merk : Neo Biotech

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Carprofen

(Synonyms: Rimadyl, Ridamyl, Imadyl) Copy Product Info

Synonyms: Rimadyl, Ridamyl, Imadyl

Catalog No. T1325 Copy Product Info

Purity: 99.65%

Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.

Cas No. 53716-49-7

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.65%

Color:White

Product Introduction

Bioactivity

Description	Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.
Targets & IC50	FAAH:78.6 μM, COX-2 (canine):30 nM, COX-1:22.3 μM
In vitro	Administration of 4 mg/kg Carprofen significantly elevated peak plasma concentrations in dogs. Compared to buprenorphine, Carprofen treatment resulted in marginally superior analgesic effects with reduced sedative action in canines. Preoperative administration of Carprofen in dogs yielded lower pain scores than other groups, with marked effectiveness observed 2 hours post-extubation. Carprofen provided sustained analgesia for 18 hours in treated canines without adverse side effects and notably improved the speed of recovery in limping birds.
In vivo	Carprofen binds to human serum albumin (HSA) via fluorescence and equilibrium dialysis methods, with two sets of binding constants [K1=5.1 μM (fluorescence) and 3.7 μM (ED), K2=37 μM (fluorescence) and 13 μM (ED)]. It predominantly binds to site II, the benzodiazepine site, while site I, the Warfarin site, exhibits a lower affinity for Carprofen. The carboxyl group of Carprofen plays a significant role in its high-affinity binding with HSA. Additionally, Carprofen (S and R enantiomers) inhibits canine COX2 with an IC50 of 0.102 microM, primarily attributed to the S enantiomer (IC50, 0.0371 μM), which is approximately 200 times more potent than the R enantiomer (IC50, 5.97 microM).
Synonyms	Rimadyl, Ridamyl, Imadyl

Chemical Properties

Molecular Weight	273.71
Formula	C₁₅H₁₂ClNO₂
Cas No.	53716-49-7
Smiles	O=C(O)C(C=1C=CC2=C(C1)NC3=CC=C(Cl)C=C32)C
Relative Density.	1.42 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 123 mg/mL (449.38 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 51 mg/mL (186.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6535 mL	18.2675 mL	36.5350 mL	182.6751 mL
5 mM	0.7307 mL	3.6535 mL	7.3070 mL	36.5350 mL
10 mM	0.3654 mL	1.8268 mL	3.6535 mL	18.2675 mL
20 mM	0.1827 mL	0.9134 mL	1.8268 mL	9.1338 mL
50 mM	0.0731 mL	0.3654 mL	0.7307 mL	3.6535 mL
100 mM	0.0365 mL	0.1827 mL	0.3654 mL	1.8268 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Fatty acid amide hydrolaseFAAHCOX-2COXCarprofenAutophagy

Related Tags: Carprofen chemical structure | Carprofen in vivo | Carprofen in vitro | Carprofen formula | Carprofen molecular weight