Reagentia en instrumenten voor immunologie, celbiologie en moleculaire biologie.

Cyclic AMP [60-92-4]

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Referentie NB-64-46282-500mg

Formaat : 500mg

Merk : Neo Biotech

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Cyclic AMP

(Synonyms: Cyclic 3',5'-monophosphate adenosine, cAMP, Adenosine Cyclophosphate, Adenosine 3',5'-cyclophosphate, 3',5'-AMP) Copy Product Info

Synonyms: Cyclic 3',5'-monophosphate adenosine, cAMP, Adenosine Cyclophosphate, Adenosine 3',5'-cyclophosphate, 3',5'-AMP

Catalog No. TCO2745 Copy Product Info

Purity: 99.99%

Cyclic AMP (cAMP) (Adenosine 3',5'-cyclophosphate) combined with vitamin C treatment of children with viral myocarditis has exact curative effect, and it can improve cardiac function of patients and improve immune function.

Cas No. 60-92-4

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.99%

Appearance:Solid

Color:White

Product Introduction

Cyclic AMP AI Summary

Cyclic AMP exhibits a range of bioactivities, including the activation of cAMP-dependent protein kinase type I and II with a binding affinity of K'a = 1.0, and bovine heart protein kinase with Ka of 8.0 M. It has specificity for phosphodiesterases in various tissues, showing Km values of 530.0 nM in bovine heart, 560.0 nM in rabbit lung, and 790.0 nM in rabbit kidney. It also inhibits Phosphodiesterase 7 (Km 200.0 nM), Phosphodiesterase 8 (Km 50.0 nM), and Phosphodiesterase 5 (Km 150,000.0 nM). Additionally, the compound demonstrates inhibitory activity against various viruses, including inhibition rates of 26.0% against L1210 and 34.0% against P388 cell lines, and some antiviral efficacy against Herpes simplex virus-2 strain MS. Furthermore, Cyclic AMP inhibits cAMP phosphodiesterase activities in various tissues with varying Km values and has noted inhibitor effects on alcohol dehydrogenase (Ki 780,000.0 nM). It activates olfactory CNG channels at 3.8 µM and exhibits potency in modulating lamin A splicing (5.0 nM) and other specific protein interactions. The compound inhibits cGMP uptake in membrane vesicles from MRP4 and MRP5-expressing cells, participates in ATP-dependent uptake of cAMP in MRP8-expressing cells, and shows specific inhibition activities against EPAC2 (IC50 40,000.0 nM), Lassa virus, and SARS-CoV-2 3CL-Pro protease at 20µM. Lastly, Cyclic AMP inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells, suggesting potential as an antiviral agent, and binds to GST-tagged EPAC1 CNBD with a Kd of 4500.0 nM, showcasing its diverse bioactivity profile across multiple biological targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cyclic AMP (cAMP) (Adenosine 3',5'-cyclophosphate) combined with vitamin C treatment of children with viral myocarditis has exact curative effect, and it can improve cardiac function of patients and improve immune function.
Synonyms	Cyclic 3',5'-monophosphate adenosine, cAMP, Adenosine Cyclophosphate, Adenosine 3',5'-cyclophosphate, 3',5'-AMP

Chemical Properties

Molecular Weight	329.21
Formula	C₁₀H₁₂N₅O₆P
Cas No.	60-92-4
Smiles	Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O
Relative Density.	2.47 g/cm3

Storage & Solubility Information

Storage

Store at low temperature,Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Insoluble

H2O: 1.65 mg/mL (5.01 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.0376 mL	15.1879 mL	30.3757 mL	151.8787 mL
5 mM	0.6075 mL	3.0376 mL	6.0751 mL	30.3757 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

InhibitorinhibitEndogenousMetaboliteEndogenous MetaboliteCyclic AMPCyclic adenosine monophosphateAdenosine cyclic 3', 5'-monophosphate

Related Tags: Cyclic AMP chemical structure | Cyclic AMP formula | Cyclic AMP molecular weight