Desmosterol [313-04-2]
Referentie NB-64-09548-1mg
Formaat : 1mg
Merk : Neo Biotech
Datasheet (EN)Desmosterol (Synonyms: Desmesterol, 24-Dehydrocholesterol)
Catalog No. T19711 Copy Product Info
Purity: 98%
Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis.
Desmosterol
Copy Product InfoSynonyms Desmesterol, 24-Dehydrocholesterol
Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis.
Cas No. 313-04-2
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Purity:98%
Appearance:Solid
Color:White
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Product Introduction
Desmosterol AI Summary
Desmosterol exhibits cytotoxicity against mouse P388 cells with an ED50 value of 33.53 µg ml⁻¹ as determined by the MTT assay, but shows ED50 values greater than 50.0 µg ml⁻¹ against human KB, A549, and HT29 cells in the same assay. It demonstrates bioactivity in Mycobacterium tuberculosis CYP enzymes, particularly CYP124A1, CYP125A1, and CYP142A1, with the highest turnover rate observed for CYP125A1 (13.29 /min). The compound's activity relative to cholesterol is highest for CYP124A1 (91.2%). Additionally, Desmosterol shows potent agonist activity at the Gal4-fused RORγt DNA binding domain in 293T cells, with an EC50 value of 80.0 nM as assessed by SRC1 coactivator recruitment in the presence of ursolic acid in a TR-FRET assay. It also acts as an orthosteric agonist at the recombinant human N-terminal His6-tagged RORγt ligand binding domain, displaying substantial binding affinity and variable effects on protein stability, indicated by changes in melting temperature (ΔTm) in the presence of different ligands. These results suggest that Desmosterol has modulatory effects on RORγt activity and protein stability..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis. |
| Synonyms | Desmesterol, 24-Dehydrocholesterol |
| Molecular Weight | 384.64 |
| Formula | C27H44O |
| Cas No. | 313-04-2 |
| Smiles | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)20)20)(CC[C@@]2([C@@H](CCC=C(C)C)C)20)20 |
| Relative Density. | 1.00 g/cm3 (Predicted) |
| Storage | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: <0.1 mg/mL (Insoluble) DMF: 10 mg/mL (26 mM), Sonication is recommended. DMSO: 1 mg/mL (2.6 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/DMF
DMF
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
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