Formaat : 50mg
Synonyms: α-difluoromethylornithine, RMI71782, MDL71782, DFMO
| Description | Eflornithine (DFMO) is a selective and orally available ornithine decarboxylase inhibitor that delays hair overgrowth.Eflornithine is used in the study of African trypanosomiasis, malignant glioma, and sleeping sickness. |
| In vivo | Eflornithine is the only newly registered molecule for the treatment of human African trypanosomiasis in the past 50 years, mainly serving as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive facial hair, eflornithine 15% cream reduces hair growth more effectively than placebo, with 58% of eflornithine users showing improvement after 24 weeks compared to 34% for placebo[2]. The hair growth inhibitory effect is significantly enhanced when eflornithine cream is applied to mouse skin pretreated with microneedles[3]. In coarctation hypertensive rats, eflornithine treatment normalizes contractile responses to KCI and norepinephrine and acetylcholine-induced relaxations after 14 days[4]. |
| Synonyms | α-difluoromethylornithine, RMI71782, MDL71782, DFMO |
| Molecular Weight | 182.17 |
| Formula | C6H12F2N2O2 |
| Cas No. | 70052-12-9 |
| Smiles | O=C(O)C(N)(CCCN)C(F)F |
| Storage | Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL (274.47 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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