Elacestrant [722533-56-4]
Referentie HY-19822-1mg
Formaat : 1mg
Merk : MedChemExpress
Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER+ breast cancer cell lines in vitro and in vivo.
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Elacestrant Chemical Structure
CAS No. : 722533-56-4
This product is a controlled substance and not for sale in your territory.
Based on 8 publication(s) in Google Scholar
Other Forms of Elacestrant:
- Elacestrant dihydrochloride In-stock
- Elacestrant S enantiomer dihydrochloride Obtenir un devis
- Elacestrant (S enantiomer) Obtenir un devis
- Elacestrant-d4 Obtenir un devis
- Elacestrant-d4-1 Obtenir un devis
- Elacestrant-d10 Obtenir un devis
- Elacestrant-d6 Obtenir un devis
Description |
Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER+ breast cancer cell lines in vitro and in vivo[1][2]. |
IC50 & Target |
IC50: 48 nM (ERα), 870 nM (ERβ)[1] |
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In Vitro |
Elacestrant (RAD1901; 0.5 nM-10 µM; 48 h) exhibits dose-dependent inhibition of ERα expression, with a EC50 of 0.6 nM in MCF-7 cells[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[1]
Western Blot Analysis[1]
Western Blot Analysis[2]
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In Vivo |
Elacestrant (0.3-120 mg/kg; p.o.; single daily for 40 days) antagonizes E2-mediated uterine stimulation in a dose-dependent manner in vivo[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Essai clinique |
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Masse moléculaire |
458.63 |
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Formule |
C30H38N2O2 |
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CAS No. |
722533-56-4 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
OC1=CC=C2C[C@H](C3=CC=C(OC)C=C3N(CC)CC4=CC=C(CCNCC)C=C4)CCC2=C1 |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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Solvant et solubilité |
In Vitro:
DMSO : 160 mg/mL (348.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation | |||||||||||||||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.1804 mL | 10.9020 mL | 21.8041 mL | 54.5102 mL |
5 mM | 0.4361 mL | 2.1804 mL | 4.3608 mL | 10.9020 mL | |
10 mM | 0.2180 mL | 1.0902 mL | 2.1804 mL | 5.4510 mL | |
15 mM | 0.1454 mL | 0.7268 mL | 1.4536 mL | 3.6340 mL | |
20 mM | 0.1090 mL | 0.5451 mL | 1.0902 mL | 2.7255 mL | |
25 mM | 0.0872 mL | 0.4361 mL | 0.8722 mL | 2.1804 mL | |
30 mM | 0.0727 mL | 0.3634 mL | 0.7268 mL | 1.8170 mL | |
40 mM | 0.0545 mL | 0.2726 mL | 0.5451 mL | 1.3628 mL | |
50 mM | 0.0436 mL | 0.2180 mL | 0.4361 mL | 1.0902 mL | |
60 mM | 0.0363 mL | 0.1817 mL | 0.3634 mL | 0.9085 mL | |
80 mM | 0.0273 mL | 0.1363 mL | 0.2726 mL | 0.6814 mL | |
100 mM | 0.0218 mL | 0.1090 mL | 0.2180 mL | 0.5451 mL |