Formaat : 500mg
Synonyms: Estradiol cypionate, Depofemin
| Description | Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor. |
| In vivo | In the field of bovine medicine, Estradiol cypionate (ECP) serves a variety of functions, including the treatment of libido deficiency due to follicular cysts, persistent corpus luteum, pyometra, and retained placenta. ECP may also aid in mitigating high-risk postpartum diseases by stimulating uterine contractions (through direct action or by maintaining oxytocin receptor sites in the uterus); enhancing uterine immune function (by increasing uterine blood flow to attract more white blood cells (WBCs) to the site of infection and augmenting the movement of IgA and IgG for bacterial phagocytosis into the uterine cavity); and promoting uterine drainage (by delaying cervical closure). Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Intramuscular administration of estradiol cypionate has been found to have the longest duration of action compared to other commonly used estradiol esters, lasting for 11 days, while estradiol benzoate and estradiol valerate have durations of 4-5 days and 7-8 days, respectively. |
| Synonyms | Estradiol cypionate, Depofemin |
| Molecular Weight | 396.56 |
| Formula | C26H36O3 |
| Cas No. | 313-06-4 |
| Smiles | C[C@]12CCC3C(CCc4cc(O)ccc34)C1CC[C@@H]2OC(=O)CCC1CCCC1 |
| Relative Density. | 1.15g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 51 mg/mL (128.61 mM), Sonication is recommended. DMSO: 257.5 mg/mL (649.33 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.04 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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