FITC-Linked Anti-Interleukin 2 Receptor Alpha (IL2Ra) Monoclonal Antibody
Referentie MBS2127025-500
Formaat : 500Tests
Merk : MyBiosource
Interleukin 2 Receptor Alpha (IL2Ra) Antibody – Mouse Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2127025MBS2127025 is an antibody targeting IL2Ra. Also known as FITC-Linked Anti-Interleukin 2 Receptor Alpha (IL2Ra) Monoclonal Antibody. Reactive in Human. Host: Mouse. More details
Product Overview
Online Datasheet in PDFProduct Name
Interleukin 2 Receptor Alpha (IL2Ra), Monoclonal Antibody
Full Product Name
FITC-Linked Anti-Interleukin 2 Receptor Alpha (IL2Ra) Monoclonal Antibody
Product Gene Name
anti-IL2Ra antibody
Product Synonym Names
IL2Ra/Interleukin 2 Receptor Alpha; CD25; IL2R-a; IL2-RA; IDDM10; IL2R; TCGFR; p55; TAC antigen
Clonality
Monoclonal
Isotype
IgG2b Kappa
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Protein A + Protein G affinity chromatography
Concentration
1mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)
Preparation and Storage
Store at 2 degree C to 8 degree C for frequent use, -20 degree C for 12 months
Molecular Weight
30,819 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (6052657..6104333, complement). Location: 10p15-p14
OMIM
147730
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Organism Species
Homo sapiens (Human)
Conjugation
FITC
Features
Flow-cytometry antibodies/FA
Product Categories/Family for anti-IL2Ra antibody
Signal transduction; CD & Adhesion molecule; Tumor immunity; Infection immunity; Primary
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-IL2Ra antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-IL2Ra antibody
For flow cytometry, the suggested use of this reagent is 1-5ul per 10^6 cells in 100ul volume.
Other Notes
Small volumes of anti-IL2Ra antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for IL2Ra. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-2 receptor subunit alpha
NCBI Official Synonym Full Names
interleukin 2 receptor, alpha
NCBI Official Symbol
IL2RA
NCBI Official Synonym Symbols
CD25; IL2R; TCGFR; IDDM10
UniProt Protein Name
Interleukin-2 receptor subunit alpha
UniProt Synonym Protein Names
TAC antigen; p55
Protein Family
Interleukin-2 receptor
UniProt Gene Name
IL2RA
UniProt Synonym Gene Names
IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA
UniProt Entry Name
IL2RA_HUMAN
NCBI Protein Information
interleukin-2 receptor subunit alpha; p55; IL2-RA; IL-2-RA; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha
NCBI Summary for IL2Ra
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
Show more UniProt Comments for IL2Ra
IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10p15-p14
Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane
Molecular Function: interleukin-2 receptor activity; drug binding; interleukin-2 binding
Biological Process: Notch signaling pathway; regulation of T cell homeostatic proliferation; apoptosis; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; cell proliferation; negative regulation of T cell proliferation; inflammatory response to antigenic stimulus; cell surface receptor linked signal transduction; positive regulation of T cell differentiation; negative regulation of inflammatory response; immune response; inflammatory response; activated T cell apoptosis
Disease: Interleukin 2 Receptor, Alpha, Deficiency Of; Diabetes Mellitus, Insulin-dependent, 10
Show more Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10p15-p14
Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane
Molecular Function: interleukin-2 receptor activity; drug binding; interleukin-2 binding
Biological Process: Notch signaling pathway; regulation of T cell homeostatic proliferation; apoptosis; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; cell proliferation; negative regulation of T cell proliferation; inflammatory response to antigenic stimulus; cell surface receptor linked signal transduction; positive regulation of T cell differentiation; negative regulation of inflammatory response; immune response; inflammatory response; activated T cell apoptosis
Disease: Interleukin 2 Receptor, Alpha, Deficiency Of; Diabetes Mellitus, Insulin-dependent, 10
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-IL2Ra antibody
| Reference Product | PubMed Publications |
|---|---|
| CD4 antibody | >2381 publications with IL2Ra and CD4 |
| IL2RB antibody | >767 publications with IL2Ra and IL2RB |
| IL2 antibody | >94 publications with IL2Ra and IL2 |
| STAT3 antibody | >28 publications with IL2Ra and STAT3 |
| ICAM1 antibody | >24 publications with IL2Ra and ICAM1 |
| STAT5B antibody | >10 publications with IL2Ra and STAT5B |
| NFKB1 antibody | >1 publications with IL2Ra and NFKB1 |
Pathways associated with anti-IL2Ra antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Arf6 Trafficking Events Pathway antibodies | Arf6 Trafficking Events Pathway Diagram |
| Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies | Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram |
| Calcium Signaling In The CD4+ TCR Pathway antibodies | Calcium Signaling In The CD4+ TCR Pathway Diagram |
| Cytokine Signaling In Immune System Pathway antibodies | Cytokine Signaling In Immune System Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Downstream Signaling In Naive CD8+ T Cells Pathway antibodies | Downstream Signaling In Naive CD8+ T Cells Pathway Diagram |
| Endocytosis Pathway antibodies | Endocytosis Pathway Diagram |
| Endocytosis Pathway antibodies | Endocytosis Pathway Diagram |
| HTLV-I Infection Pathway antibodies | HTLV-I Infection Pathway Diagram |
Diseases associated with anti-IL2Ra antibody
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >445 publications with IL2Ra and Inflammation |
| Necrosis Antibodies | >304 publications with IL2Ra and Necrosis |
| Lung Diseases Antibodies | >163 publications with IL2Ra and Lung Diseases |
| Liver Diseases Antibodies | >138 publications with IL2Ra and Liver Diseases |
| Diabetes Mellitus, Type 1 Antibodies | >132 publications with IL2Ra and Diabetes Mellitus, Type 1 |
| Multiple Sclerosis Antibodies | >112 publications with IL2Ra and Multiple Sclerosis |
| Arthritis, Rheumatoid Antibodies | >108 publications with IL2Ra and Arthritis, Rheumatoid |
| Vascular Diseases Antibodies | >89 publications with IL2Ra and Vascular Diseases |
| HIV Infections Antibodies | >74 publications with IL2Ra and HIV Infections |
| Kidney Diseases Antibodies | >73 publications with IL2Ra and Kidney Diseases |
Organs/Tissues associated with anti-IL2Ra antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >3210 publications with IL2Ra and Blood |
| Spleen Antibodies | >353 publications with IL2Ra and Spleen |
| Lymph Node Antibodies | >271 publications with IL2Ra and Lymph Node |
| Bone Antibodies | >214 publications with IL2Ra and Bone |
| Bone Marrow Antibodies | >201 publications with IL2Ra and Bone Marrow |
| Thymus Antibodies | >195 publications with IL2Ra and Thymus |
| Lung Antibodies | >188 publications with IL2Ra and Lung |
| Mixed Antibodies | >149 publications with IL2Ra and Mixed |
| Brain Antibodies | >97 publications with IL2Ra and Brain |
| Uterus Antibodies | >26 publications with IL2Ra and Uterus |