Goat Anti-LMNB1 / Lamin B1 (aa526-537) Polyclonal Antibody
Referentie ALS16291
Formaat : 50ug
Merk : Abcepta
LMNB1 / Lamin B1 Antibody (aa526-537)
Goat Polyclonal Antibody
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LMNB1 antibody (1 ug/ml) staining of nuclear HeLa lysate (35 ug protein in RIPA buffer).
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Anti-LMNB1 / Lamin B1 antibody IHC staining of human uterus.
LMNB1 antibody (1 ug/ml) staining of nuclear HeLa lysate (35 ug protein in RIPA buffer).
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P20700 |
| Reactivity | Human, Rabbit, Hamster, Pig, Horse, Xenopus, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 66kDa |
| Dilution | ELISA (1:64000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml) |
| Gene ID | 4001 |
|---|---|
| Other Names | Lamin-B1, LMNB1, LMN2, LMNB |
| Target/Specificity | Human LMNB1 / Lamin B1. This antibody is expected to recognize both reported isoforms (NP_005564.1; NP_001185486.1). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | LMNB1 / Lamin B1 Antibody (aa526-537) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LMNB1 |
|---|---|
| Synonyms | LMN2, LMNB |
| Function | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). Plays a role in sperm morphological development during late stages of spermiogenesis, particularly the anchoring of the sperm head to the tail (PubMed:38870534). Component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during spermiogenesis (PubMed:38870534). |
| Cellular Location | Nucleus lamina. Note=Expressed in the posterior part of the nucleus during mid-steps of spermiogenesis, expression becomes more localized to the implantation fossa in later stages (By similarity) Expressed at the neck region in mature sperm (By similarity) {ECO:0000250|UniProtKB:P14733} |
Research Areas
- Primary Antibodies
- Cell Biology
- Signal Transduction
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