Human Growth Hormone Releasing Hormone
Referentie MBS142629-5mg
Formaat : 5mg
Merk : MyBiosource
Growth Hormone (GHRH) Human Active Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142629Description: Growth Hormone Releasing Hormone Human Synthetic is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 3358.9 Dalton.Corresponds to the amino-terminal segment of the naturally occurring human… More details
Product Overview
Online Datasheet in PDFProduct Name
Growth Hormone (GHRH), Active Protein
Full Product Name
Human Growth Hormone Releasing Hormone
Product Gene Name
GHRH active protein
Product Synonym Names
GHRH Human; Growth Hormone Releasing Hormone Human; Somatoliberin; Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH; Somatocrinin; Somatorelin; Sermorelin; GHRF; MGC119781
Sequence
The free base of sermorelin has the empirical formula C149H246N 44O42STyr- Ala-Asp-Al a-Ile-Phe- Thr-Asn-Se r-Tyr-Arg- Lys-Val-Le u-Gly-Gln- Leu-Ser-Al a-Arg-Lys- Leu-Leu-Gl n-Asp-Ile- Met-Ser-Ar g-NH2
Form/Format
The protein (1mg/ml) was lyophilized after extensive dialyses against 1.7 mg sodium phosphate buffer (0.1mg sodium phosphate monobasic & 1.6 sodium phosphate dibasic).
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Concentration
1mg/ml (lot specific)
Preparation and Storage
Lyophilized Growth Hormone Releasing Hormone although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution GHRF should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Molecular Weight
12,360 Da
OMIM
139190
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
It is recommended to reconstitute the lyophilized GHRH in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. The GHRH is also soluble in 1% Acetic acid at a concentration of >1mg/ml to give a clear, colorless solution.
Biological Activity
GHRH increases plasma growth hormone concentrations by directly stimulating the anterior pituitary gland to release natural human growth hormone.
Product Categories/Family for GHRH active protein
Hormones; Hormones; GHRP
Other Notes
Small volumes of GHRH active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for GHRH purchase
MBS142629 is an active protein targeting GHRH. Also known as Human Growth Hormone Releasing Hormone.
Additional Details
NCBI/Uniprot data below describe general gene information for GHRH. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
somatoliberin isoform 2 preproprotein
NCBI Official Synonym Full Names
growth hormone releasing hormone
NCBI Official Symbol
GHRH
NCBI Official Synonym Symbols
GRF; INN; GHRF
UniProt Protein Name
Somatoliberin
UniProt Synonym Protein Names
Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH; Somatocrinin; Somatorelin; INN: Sermorelin
Protein Family
Somatoliberin
UniProt Gene Name
GHRH
UniProt Synonym Gene Names
GHRF; GRF; GHRH
UniProt Entry Name
SLIB_HUMAN
NCBI Protein Information
somatoliberin; growth hormone-releasing factor; growth hormone-releasing hormone; sermorelin; somatocrinin; somatorelin
NCBI Summary for GHRH
The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for GHRH
GHRH: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. Belongs to the glucagon family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 20q11.2
Cellular Component: extracellular space; extracellular region; terminal button
Molecular Function: growth hormone-releasing hormone activity; growth hormone-releasing hormone receptor binding
Biological Process: response to food; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of growth hormone secretion; growth hormone secretion; cAMP-mediated signaling; positive regulation of circadian sleep/wake cycle, REM sleep; cell-cell signaling; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; adenohypophysis development; positive regulation of multicellular organism growth; G-protein signaling, adenylate cyclase activating pathway
Show more Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 20q11.2
Cellular Component: extracellular space; extracellular region; terminal button
Molecular Function: growth hormone-releasing hormone activity; growth hormone-releasing hormone receptor binding
Biological Process: response to food; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of growth hormone secretion; growth hormone secretion; cAMP-mediated signaling; positive regulation of circadian sleep/wake cycle, REM sleep; cell-cell signaling; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; adenohypophysis development; positive regulation of multicellular organism growth; G-protein signaling, adenylate cyclase activating pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with GHRH active protein
| Reference Product | PubMed Publications |
|---|---|
| TRH active protein | >258 publications with GHRH and TRH |
| CRH active protein | >157 publications with GHRH and CRH |
| POMC active protein | >155 publications with GHRH and POMC |
| GHRHR active protein | >58 publications with GHRH and GHRHR |
| SST active protein | >35 publications with GHRH and SST |
| ADCYAP1 active protein | >24 publications with GHRH and ADCYAP1 |
| GHSR active protein | >11 publications with GHRH and GHSR |
| SCT active protein | >5 publications with GHRH and SCT |
| GHRL active protein | >3 publications with GHRH and GHRL |
| GCG active protein | >3 publications with GHRH and GCG |
Pathways associated with GHRH active protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Class B/2 (Secretin Family Receptors) Pathway antibodies | Class B/2 (Secretin Family Receptors) Pathway Diagram |
| Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies | Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram |
| Disease Pathway antibodies | Disease Pathway Diagram |
| G Alpha (s) Signalling Events Pathway antibodies | G Alpha (s) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| Glucagon-type Ligand Receptors Pathway antibodies | Glucagon-type Ligand Receptors Pathway Diagram |
| Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies | Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram |
| Signal Transduction Pathway antibodies | Signal Transduction Pathway Diagram |
| Signaling By GPCR Pathway antibodies | Signaling By GPCR Pathway Diagram |
Diseases associated with GHRH active protein
| Disease Name | Pubmed Publications |
|---|---|
| Adenoma Antibodies | >210 publications with GHRH and Adenoma |
| Insulin Resistance Antibodies | >95 publications with GHRH and Insulin Resistance |
| Diabetes Mellitus Antibodies | >84 publications with GHRH and Diabetes Mellitus |
| Hyperplasia Antibodies | >62 publications with GHRH and Hyperplasia |
| Respiratory Tract Diseases Antibodies | >61 publications with GHRH and Respiratory Tract Diseases |
| Weight Gain Antibodies | >59 publications with GHRH and Weight Gain |
| Adenocarcinoma Antibodies | >59 publications with GHRH and Adenocarcinoma |
| Congenital Abnormalities Antibodies | >56 publications with GHRH and Congenital Abnormalities |
| Hypothyroidism Antibodies | >56 publications with GHRH and Hypothyroidism |
| Weight Loss Antibodies | >44 publications with GHRH and Weight Loss |
Organs/Tissues associated with GHRH active protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Lung Antibodies | >57 publications with GHRH and Lung |
| Mixed Antibodies | >30 publications with GHRH and Mixed |