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> Human KRAS (V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog) Sandwich ELISA Kit

Human KRAS (V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog) Sandwich ELISA Kit

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Referentie NB-22-65755-48

Formaat : 48T

Merk : Neo Biotech


Short Description :This KRAS Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids..
Applications:ELISA
Reactivity:Human
Sensitivity:0.113ng/mL
Detection Limit:0.312-20ng/mL
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Storage Instruction:Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:4.5 hrs
Gene Symbol:
Gene ID:
Uniprot ID:
Sample Type:serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs). Palmitoylated at Lys-182, Lys-184 and Lys-185. Palmitoylation on lysine residues is promoted by palmitoylation at Cys-180. Lysine-depalmitoylation by SIRT2 promotes its localization to endomembranes in endocytic pathways. Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes. (Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL.
Function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.
Protein Name Gtpase Kras
K-Ras 2
Ki-Ras
C-K-Ras
C-Ki-Ras Cleaved Into - Gtpase Kras - N-Terminally Processed
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Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Endomembrane System
Cytoplasm
Cytosol
Isoform 2b: Cell Membrane
Alternative ELISA Names Gtpase Kras ELISA kit
K-Ras 2 ELISA kit
Ki-Ras ELISA kit
C-K-Ras ELISA kit
C-Ki-Ras Cleaved Into - Gtpase Kras - N-Terminally Processed ELISA kit
KRAS ELISA kit
KRAS2 ELISA kit
RASK2 ELISA kit
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Information sourced from Uniprot.org

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