Indole-3-butyric acid [133-32-4]
Referentie NB-64-34172-10g
Formaat : 10g
Merk : Neo Biotech
Datasheet (EN)Indole-3-butyric acid (Synonyms: IBA, Hormodin, 3-Indolebutyric acid)
Catalog No. T6361 Copy Product Info
Purity: 99.92%
Indole-3-butyric acid (IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.
Indole-3-butyric acid
Copy Product InfoSynonyms IBA, Hormodin, 3-Indolebutyric acid
Indole-3-butyric acid (IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.
Cas No. 133-32-4
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Purity:99.92%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Indole-3-butyric acid AI Summary
Indole-3-butyric acid exhibits a broad spectrum of bioactivities. It acts as an antagonist at the human T1R2/T1R3 receptor with an IC50 value greater than 1,000,000 nM, inhibiting sucralose-induced intracellular calcium mobilization in HEK293E cells. In receptor-based assays, it shows agonist activity towards retinoid X receptor alpha, estrogen receptor alpha, androgen receptor, peroxisome proliferator-activated receptor delta and gamma, and the ARE signaling pathways, with potencies ranging from 13.3 nM to 61,130.6 nM. It also displays antagonist activity towards the androgen receptor. For enzymatic inhibition, Indole-3-butyric acid inhibits electric eel AChE (-10.87%) and horse BChE (-5.54%) at 2 mg/mL. In terms of antibacterial properties, it inhibits metallo-beta-lactamase VIM-2 from Pseudomonas aeruginosa, with an IC50 of 757,000 nM and Kd of 274,000 nM, as well as Klebsiella pneumoniae NDM-1 with an IC50 of 1,946,000 nM and Kd of 806,000 nM. Moreover, it shows activity against Klebsiella pneumoniae OXA-48 (IC50 of 480,000 nM, Kd of 430,000 nM) and LOX with an IC50 of 17,820 nM. In antiviral assays, Indole-3-butyric acid inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 16.23% at 10 µM after 48 hours, but demonstrates significantly lower inhibition in VERO-6 cells (-0.05%). For SARS-CoV-2 3CL-Pro protease, it shows 1.767% inhibition at 20 µM. Additionally, it has fungicidal activity against various fungi like Macrophomina phaseoli, Rhizoctonia solani, Pythium debaryanum, and Fusarium culmorum with IC50 values ranging from 249.0 to 699.0 µg/mL, and promotes root formation in Vigna mungo cuttings at 1 x 10^-4 M, matching the activity of IBA. Finally, it exhibits inhibitory activity against the human HDAC6 enzyme with -15.75% inhibition in one enzymatic assay and -2.0% in another..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Indole-3-butyric acid (IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products. |
| Synonyms | IBA, Hormodin, 3-Indolebutyric acid |
| Molecular Weight | 203.24 |
| Formula | C12H13NO2 |
| Cas No. | 133-32-4 |
| Smiles | OC(=O)CCCC1=CNC2=CC=CC=C12 |
| Relative Density. | 1.1255 g/cm3 (Estimated) |
| Storage | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 39 mg/mL (191.89 mM), Sonication is recommended. DMSO: 50 mg/mL (246.01 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (12.3 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
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