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Isopropyl myristate [110-27-0]

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Referentie NB-64-09813-50g

Formaat : 50g

Merk : Neo Biotech

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Isopropyl myristate

(Synonyms: Stepan D-50, NSC 406280, Isomyst, IPM, HSDB 626, FEMA No. 3556) Copy Product Info

Synonyms: Stepan D-50, NSC 406280, Isomyst, IPM, HSDB 626, FEMA No. 3556

Catalog No. T20005 Copy Product Info

Purity: 99.86%

Isopropyl Myristate (IPM) is a fatty acid ester formed by esterification of isopropanol and myristic acid. It is a polar emollient that enhances the application and feel of the formulation, and helps in the dispersion of active ingredients.

Cas No. 110-27-0

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.86%

Appearance:Liquid

Color:Transparent

Product Introduction

Isopropyl myristate AI Summary

Isopropyl myristate exhibits broad-spectrum antibacterial activity against Staphylococcus aureus, Micrococcus luteus, and Escherichia coli with minimal inhibitory concentrations (MICs) of 2238721.14 nM, 2238721.14 nM, and 3715352.29 nM, respectively. It demonstrates significant bioactivities, including modulating Lamin A splicing with a potency of 562.3 nM, inhibiting GCN5L2 at 31622.8 nM, acting as a small molecule agonist of androgen receptor signaling with a potency of 28.2 nM, and antagonizing thyroid hormone receptor beta signaling at 281.8 nM. Furthermore, Isopropyl myristate shows antiviral properties, capable of blocking Ebola virus entry with an AC50 of 0.631 µM. It also inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 7.23% at 10 µM and exhibits a modest inhibition rate of 0.15% in VERO-6 cells under the same conditions. Additionally, it targets the SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 7.206% at 20 µM. Isopropyl myristate further inhibits the human HDAC6 enzyme with inhibition rates of 30.53% using a commercial peptide substrate and 2.55% with a custom peptide substrate, indicating potential utility in therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isopropyl Myristate (IPM) is a fatty acid ester formed by esterification of isopropanol and myristic acid. It is a polar emollient that enhances the application and feel of the formulation, and helps in the dispersion of active ingredients.
Synonyms	Stepan D-50, NSC 406280, Isomyst, IPM, HSDB 626, FEMA No. 3556

Chemical Properties

Molecular Weight	270.45
Formula	C₁₇H₃₄O₂
Cas No.	110-27-0
Smiles	CCCCCCCCCCCCCC(=O)OC(C)C
Relative Density.	853.2 kg/m3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (203.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6975 mL	18.4877 mL	36.9754 mL	184.8771 mL
5 mM	0.7395 mL	3.6975 mL	7.3951 mL	36.9754 mL
10 mM	0.3698 mL	1.8488 mL	3.6975 mL	18.4877 mL
20 mM	0.1849 mL	0.9244 mL	1.8488 mL	9.2439 mL
50 mM	0.0740 mL	0.3698 mL	0.7395 mL	3.6975 mL
100 mM	0.0370 mL	0.1849 mL	0.3698 mL	1.8488 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

NSC-406280NSC406280Isopropyl myristateInhibitorinhibitHSDB-626HSDB626

Related Tags: Isopropyl myristate chemical structure | Isopropyl myristate formula | Isopropyl myristate molecular weight