Reagentia en instrumenten voor immunologie, celbiologie en moleculaire biologie.

ITX5061 [1252679-52-9]

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Referentie NB-64-06838-1mg

Formaat : 1mg

Merk : Neo Biotech

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ITX5061

(Synonyms: ITX-5061) Copy Product Info

Synonyms: ITX-5061

Catalog No. T15603 Copy Product Info

Purity: 99.50%

ITX5061 is a type II inhibitor of p38 MAPK and an antagonist of scavenger receptor B1 (SRB1), used for studying hepatitis C virus infection.

Cas No. 1252679-52-9

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.50%

Appearance:Solid

Color:Yellow

Product Information

Bioactivity

Description	ITX5061 is a type II inhibitor of p38 MAPK and an antagonist of scavenger receptor B1 (SRB1), used for studying hepatitis C virus infection.
In vivo	HuAITg mice were treated with ITX5061 (30 mg/kg/day) or vehicle for one week. This resulted in a 50% increase in HDL-C levels, while non-HDL-C levels remained unchanged[1].
Synonyms	ITX-5061

Chemical Properties

Molecular Weight	620.16
Formula	C₃₀H₃₈ClN₃O₇S
Cas No.	1252679-52-9
Smiles	Cl.COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (80.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6125 mL	8.0624 mL	16.1249 mL	80.6244 mL
5 mM	0.3225 mL	1.6125 mL	3.2250 mL	16.1249 mL
10 mM	0.1612 mL	0.8062 mL	1.6125 mL	8.0624 mL
20 mM	0.0806 mL	0.4031 mL	0.8062 mL	4.0312 mL
50 mM	0.0322 mL	0.1612 mL	0.3225 mL	1.6125 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Please see Product Handling Instructions for more frequentl