Reagentia en instrumenten voor immunologie, celbiologie en moleculaire biologie.
 
> Kinetin riboside [4338-47-0]

Kinetin riboside [4338-47-0]

Afdrukken Afdrukken
Log in alstublieft

Referentie orb1225058-500mg

Formaat : 500mg

Merk : Biorbyt


Kinetin riboside

SKU: orb1225058

Description

A cytokinin analog that displays potent antiproliferative activity against various human cancer cell lines; inhibits MiPaCa-2 cell proliferation with IC50 of 0.27 uM; induceds marked suppression of CCND2 transcription and rapidly suppresses cyclin D1 and D2 protein expression in primary myeloma cells and tumor lines, causing cell cycle arrest, tumor cell-selective apoptosis, and inhibition of myeloma growth in xenografted mice; also can activate PINK1 in cells independent of mitochondrial depolarization.

Research Area

Pharmacology & Drug Discovery

Images & Validation

−
Kinetin riboside

Key Properties

−
CAS Number4338-47-0
MW347.32598
Purity>98% (HPLC)
FormulaC15H17N5O5
SMILESO[C@H]1[C@H](N2C=NC3=C(NCC4=CC=CO4)N=CN=C23)O[C@H](CO)[C@H]1O
TargetApoptosis
SolubilityDMSO: ≥ 29 mg/mL

Bioactivity

−
In Vivo
Kinetin riboside significantly suppresses tumor growth. The most effective anti-melanoma response is elicited at 40 mg/kg.
In Vitro
Kinetin riboside displays antiproliferative and apoptogenic activity against various human cancer cell lines. Kinetin riboside is able to inhibit the proliferation in HCT-15 human colon cancer cells in a dose-dependent manner (IC50 = 2.5 μM). Kinetin riboside induces apoptosis in HeLa and mouse melanoma B16F-10 cells. Kinetin riboside disrupts the mitochondrial membrane potential and induces the release of cytochrome c and activation of caspase-3. Bad are up-regulated while Bcl-2 is down-regulated under kinetin riboside exposure.

Storage & Handling

−
StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
N6-Furfuryladenosine | FAdo
−
  • 8-Azakinetin riboside

    8-Azakinetin riboside [orb2567141]

    2347524-00-7

    348.31

    C14H16N6O5

    50 mg, 10 mg
  • N-6-Furfurylguanosine

    N-6-Furfurylguanosine [orb1908942]

    99.15% (May vary between batches)

    26783-39-1

    362.34

    C15H18N6O5

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg
  • Kinetin riboside

    Kinetin riboside [orb1299907]

    98.17% (May vary between batches)

    4338-47-0

    347.33

    C15H17N5O5

    25 mg, 1 ml x 10 mM (in DMSO)

Quick Database Links

Gene Symbol
Apoptosis

Protocol Information