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> LAP TFA

LAP TFA

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Referentie T83714-1mg

Formaat : 1mg

Merk : TargetMol


LAP TFA

(Synonyms: Lupus Autoantigen Peptide, La Peptide) Copy Product Info
Lupus autoantigen peptide (LAP), a derivative of the autoantigen La found in systemic lupus erythematosus (SLE) patients, spans amino acids 11-28 of La and functions as an antiviral peptide. It primarily blocks the hepatitis C virus (HCV) from interacting with internal ribosome entry site (IRES) trans-acting factors (ITAFs), notably the polypyrimidine tract-binding protein (PTB) and poly(rC)-binding protein 2 (PCBP2). In a Huh7 cell-based reporter assay, LAP at a concentration of 60 µM effectively hampers HCV IRES-mediated translation, a process reversible by adding recombinant forms of PTB and PCBP2.
LAP TFA
Other Forms of LAP TFA:
TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
LAP
Latent TGF beta 1 Protein, Human, Recombinant (His)
Prostatic Acid Phosphatase Protein, Mouse, Recombinant (His)
LAP3 Protein, Human, Recombinant (His)
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated
For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity
Description
Lupus autoantigen peptide (LAP), a derivative of the autoantigen La found in systemic lupus erythematosus (SLE) patients, spans amino acids 11-28 of La and functions as an antiviral peptide. It primarily blocks the hepatitis C virus (HCV) from interacting with internal ribosome entry site (IRES) trans-acting factors (ITAFs), notably the polypyrimidine tract-binding protein (PTB) and poly(rC)-binding protein 2 (PCBP2). In a Huh7 cell-based reporter assay, LAP at a concentration of 60 µM effectively hampers HCV IRES-mediated translation, a process reversible by adding recombinant forms of PTB and PCBP2.
SynonymsLupus Autoantigen Peptide, La Peptide
Chemical Properties
Molecular Weight2117.40
FormulaC99H141N23O27S.XCF3COOH
SmilesOC(C(F)(F)F)=O.C[C@H](N)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@@](19)([C@H](CC)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](19)([C@H](CC)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N)=O)=O)CC(O)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)CC4=CC=C(C=C4)O)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)CC5=CNC=N5)=O)CS19)=O)=O)CCCCN)=O)=O)CCC(O)=O)=O)=O)=O
Storage & Solubility Information
StorageKeep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mg/mL (4.72 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.4723 mL2.3614 mL4.7228 mL23.6139 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.