LNK Polyclonal Antibody
Referentie bs-13651R
Formaat : 100uL
Merk : Bioss
Applications
Predicted Reactivity
| Overview | |
| Catalog # | bs-13651R-100uL |
| Product Name | LNK Polyclonal Antibody |
| Applications | WB ELISA IHC-P IHC-F IF(IHC-P) IF(IHC-F) IF(ICC) |
| Predicted Reactivity | Human, Mouse, Rat, Dog, Cow, Sheep, Horse, Monkey |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human LNK |
| Immunogen Range | 161-260/576 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. |
| Target | |
| Subcellular location | Cell membrane |
| Synonyms | IDDM20;Lymphocyte adapter protein;Lymphocyte specic adapter protein;Lymphocyte specic adapter protein Lnk;Lymphocyte-specic adapter protein Lnk;SH2B adapter protein 3;SH2B adaptor protein 3;Sh2b3;SH2B3_HUMAN;Signal transduction protein Lnk. |
| Background | APS (adapter molecule containing PH and SH2 domains), SH2-B and Lnk compose a family of adapter proteins, which contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. Stimulation of B cell receptor (BCR) or T cell receptor (TCR) results in the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of BCR, TCR and several substrates. APS, SH2-B and Lnk may bind to the ITAM domain of BCR and TCR. Lnk is tyrosine phosphorylated in response to TCR stimulation and APS has been shown to be tyrosine phosphorylated in response to BCR stimulation. |
| Application Dilution | |
| WB | 1:300-5000 |
| ELISA | 1:500-1000 |
| IHC-P | 1:200-400 |
| IHC-F | 1:100-500 |
| IF(IHC-P) | 1:50-200 |
| IF(IHC-F) | 1:50-200 |
| IF(ICC) | 1:50-200 |