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Monobenzone [103-16-2]

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Referentie NB-64-00921-10g

Formaat : 10g

Merk : Neo Biotech

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Monobenzone

(Synonyms: Benoquin) Copy Product Info

Synonyms: Benoquin

Catalog No. T0759 Copy Product Info

Purity: 99.87%

Monobenzone (Benoquin) is a Depigmenting Agent. The mechanism of action of monobenzone is as a Melanin Synthesis Inhibitor. The physiologic effect of monobenzone is by means of Depigmenting Activity.

Cas No. 103-16-2

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.87%

Appearance:Solid

Color:White

Product Introduction

Monobenzone AI Summary

Monobenzone exhibits a diverse range of bioactivities and inhibitory properties across multiple biological targets. It has a significant inhibitory effect on the recombinant rat androgen receptor expressed in Escherichia coli with an IC50 value of 234422.88 nM. The compound shows potent modulation of Lamin A splicing, induces erasure of genomic imprints with moderate potency, and has both inhibitory and potential substrate activity towards Cytochrome P450 2C19. Additionally, Monobenzone displays agonistic and antagonistic activities in the Hypoxia Response Element signaling pathway and has been identified as a potential novel general anesthetic. In various enzyme inhibition assays, Monobenzone exhibits inhibition of COX-1 (IC50: 1019.0 nM), COX-2 (IC50: 3726.0 nM), Lipoxygenase 15-LO (IC50: 4892.0 nM), and Norepinephrine Transporter with an IC50 value of 3886.0 nM and a Ki value of 3854.0 nM. However, it shows no significant hepatic toxicity based on the Drug Induced Liver Injury Prediction System (DILIps). Monobenzone is active in assays related to Cytochrome P450 isoforms including p450-cyp2c19 and p450-cyp1a2 and demonstrates moderate inhibition of the malarial parasite plastid. It also has activity in Schwann cell assays, inhibits human tyrosyl-DNA phosphodiesterase 1, affects Plasmodium falciparum proliferation, and interferes with the binding or cellular entry of the Lassa and Ebola viruses. In the context of SARS-CoV-2, Monobenzone shows low bioactivity in inhibiting cell viability of Vero E6 cells infected with the virus, with inhibition percentages and IC50 values below the thresholds of significant activity. However, it does exhibit inhibitory activity against the SARS-CoV-2 3CL-Pro protease with a modest inhibition percentage. Notably, Monobenzone demonstrates potent inhibitory activity against human HDAC6 in various enzymatic assays, with inhibition percentages of 98.06%, 87.0%, and 86.56%, and an IC50 value of 988.8 nM with a custom peptide substrate, underscoring its high potency and selectivity as an HDAC6 inhibitor. Additionally, the compound binds to human SLC6A3 and SLC6A2 with AC50 values of 8556.0 nM and 6955.0 nM, respectively, and inhibits human PTGS1 with AC50 values measured at 10953.4 nM and 7876.3 nM through different detection methods..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Monobenzone (Benoquin) is a Depigmenting Agent. The mechanism of action of monobenzone is as a Melanin Synthesis Inhibitor. The physiologic effect of monobenzone is by means of Depigmenting Activity.
Synonyms	Benoquin

Chemical Properties

Molecular Weight	200.23
Formula	C₁₃H₁₂O₂
Cas No.	103-16-2
Smiles	OC1=CC=C(OCC2=CC=CC=C2)C=C1
Relative Density.	1.26

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 38 mg/mL (189.78 mM), Sonication is recommended.

DMSO: 250 mg/mL (1248.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (49.94 mM), Solution.

10% DMSO+90% Saline: < 10 mg/mL (49.94 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9943 mL	24.9713 mL	49.9426 mL	249.7128 mL
5 mM	0.9989 mL	4.9943 mL	9.9885 mL	49.9426 mL
10 mM	0.4994 mL	2.4971 mL	4.9943 mL	24.9713 mL
20 mM	0.2497 mL	1.2486 mL	2.4971 mL	12.4856 mL
50 mM	0.0999 mL	0.4994 mL	0.9989 mL	4.9943 mL
100 mM	0.0499 mL	0.2497 mL	0.4994 mL	2.4971 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

vitiligoTyrosinaseskinMonobenzoneInhibitorinhibitdepigmentingdepigmentation

Related Tags: Monobenzone chemical structure | Monobenzone formula | Monobenzone molecular weight