Reagentia en instrumenten voor immunologie, celbiologie en moleculaire biologie.

Neuropathiazol [880090-88-0]

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Referentie NB-64-07364-50mg

Formaat : 50mg

Merk : Neo Biotech

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Neuropathiazol

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Synonyms:

Catalog No. T16288 Copy Product Info

Purity: 99.86%

Neuropathiazol causes neuronal differentiation of adult hippocampal neural progenitor cells.

Cas No. 880090-88-0

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.86%

Appearance:Solid

Color:Yellow

Product Introduction

Bioactivity

Description	Neuropathiazol causes neuronal differentiation of adult hippocampal neural progenitor cells.
In vitro	In HCN cells, Neuropathiazol (5, 10, and 15 μM) significantly slows cell proliferation and inhibits the proliferation of HCN neural progenitor cells. Neuropathiazol (10 μM) down-regulates Sox2, up-regulates NeuroD1, and inhibits the differentiation of astroglial induced by LIF and BMP2[1].

Chemical Properties

Molecular Weight	338.42
Formula	C₁₉H₁₈N₂O₂S
Cas No.	880090-88-0
Smiles	CCOC(=O)C1=CC=C(C=C1)N(C)C1=CSC(=N1)C1=CC=CC=C1
Relative Density.	1.224 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (147.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9549 mL	14.7745 mL	29.5491 mL	147.7454 mL
5 mM	0.5910 mL	2.9549 mL	5.9098 mL	29.5491 mL
10 mM	0.2955 mL	1.4775 mL	2.9549 mL	14.7745 mL
20 mM	0.1477 mL	0.7387 mL	1.4775 mL	7.3873 mL
50 mM	0.0591 mL	0.2955 mL	0.5910 mL	2.9549 mL
100 mM	0.0295 mL	0.1477 mL	0.2955 mL	1.4775 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Keywords

Neuropathiazol

Related Tags: Neuropathiazol chemical structure | Neuropathiazol in vitro | Neuropathiazol formula | Neuropathiazol molecular weight