Notch 1 Protein, Mouse, Recombinant (hFc)
Referentie NB-64-55640-20ug
Formaat : 20ug
Merk : Neo Biotech
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Notch 1 Protein, Mouse, Recombinant (hFc)
(Synonyms: Tan1, Notch1, notch 1, N1, Mis6, lin-12, 9930111A19Rik) Copy Product InfoSynonyms: Tan1, Notch1, notch 1, N1, Mis6, lin-12, 9930111A19Rik
Catalog No. TMPY-00415 Copy Product Info
Notch 1 Protein, Mouse, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 80.6 kDa and the accession number is Q01705-1.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Notch 1 Protein, Mouse, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 80.6 kDa and the accession number is Q01705-1. |
| Species | Mouse |
| Expression System | CHO Cells |
| Tag | C-hFc |
| Accession Number | Q01705-1 |
| Construction | A DNA sequence encoding the mouse Notch1 (NP_032740.3) (Met1-Gln526) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Ala 19 |
| Protein Purity | > 90 % as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | Tan1, Notch1, notch 1, N1, Mis6, lin-12, 9930111A19Rik |
| Research Background | NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair the regeneration of skeletal muscles.NOTCH1 is a prevalent signaling pathway in T cell acute lymphoblastic leukemia (T-ALL). The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems. The proto-oncogene NOTCH1 is frequently mutated in around 10% of patients with chronic lymphocytic leukemia (CLL). NOTCH1 mutations in oral squamous cell carcinoma (OSCC) frequently occur near the ligand-binding region. These mutations change the domain structure of this protein and affect the ligand-binding activity. When NOTCH1 is activated by ligand binding, the NOTCH1 intracellular domain (NICD) is cleaved from the cell membrane. |
| Molecular Weight | 80.6 kDa (predicted) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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N-1N 1
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Related Tags: Notch 1 Protein, Mouse, Recombinant (hFc) chemical structure | Notch 1 Protein, Mouse, Recombinant (hFc) molecular weight
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