Formaat : 1mg
Synonyms: ODN-1826, ODN1826
| Description | ODN 1826 is a 20-mer DNA strand, a TLR9 agonist and an immunostimulant, with anti-tumor and cardioprotective effects, promoting apoptosis, and stimulating the production of NO and iNOS. ODN 1826 is a CpG DNA mimetic that can be used as an adjuvant for synthetic vaccines. |
| In vivo | Eight to twelve week old C57BL/6J wild-typ (WT) mice. To determine the required ODN 1826 concentration for a proinflammatory response, WT mice were injected intravenously (i.v.) with 3nM, 10nM, or 30nM ODN 1826 suspended in 200μl phosphate buffered saline (PBS) or vehicle (PBS). Dose-dependent IL-6 induction and 30nM ODN 1826 led to the highest IL-6 formation. [1] |
| Synonyms | ODN-1826, ODN1826 |
| Cas No. | 202668-42-6 |
| Storage | Store at low temperature,Keep away from moisture, Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: 50 mg/mL, Sonication is recommended. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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