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> PDGFRA Protein, Rat, Recombinant (hFc)

PDGFRA Protein, Rat, Recombinant (hFc)

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PDGFRA Protein, Rat, Recombinant (hFc)

(Synonyms: platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide) Copy Product Info

Synonyms: platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide

Catalog No. TMPY-03919 Copy Product Info
PDGFRA Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.2 kDa and the accession number is G3V6A0.
Other Forms of PDGFRA Protein, Rat, Recombinant (hFc):
PDGFRA Protein, Human, Recombinant (hFc)
PDGFRA Protein, Human, Recombinant (His)
PDGFRA Protein, Rat, Recombinant (His)
PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
PDGFRA Protein, Mouse, Recombinant (His)
PDGFRA Protein, Mouse, Recombinant (hFc)
PDGFRA Protein, Cynomolgus, Recombinant (His)
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Bioactivity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
PDGFRA Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.2 kDa and the accession number is G3V6A0.
Species
Rat
Expression System
HEK293 Cells
TagC-hFc
Accession NumberG3V6A0
ConstructionA DNA sequence encoding the rat PDGFRA (G3V6A0) (Met1-Glu523) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Leu 24
Protein Purity
> 95% as determined by SDS-PAGE
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonymsplatelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide
Research Background
PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Chemical Properties
Molecular Weight83.2 kDa (predicted); 112-120 kDa (reducing condition, due to glycosylation)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Related Tags: PDGFRA Protein, Rat, Recombinant (hFc) chemical structure | PDGFRA Protein, Rat, Recombinant (hFc) molecular weight