Polyclonal Antibody to Phospholipase A2 Receptor 1 (PLA2R1)
Referentie MBS2017615-0,1mL
Formaat : 0.1mL
Merk : MyBiosource
Western Blot;
Sample: Recombinant PLA2R1, Human.
Sample: Recombinant PLA2R1, Human.
Phospholipase A2 Receptor 1 (PLA2R1) Antibody – Rabbit
For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2017615SPECIAL PROMOTION: Get FREE Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment
MBS2017615 is an antibody targeting PLA2R1. Also known as Polyclonal Antibody to Phospholipase A2 Receptor 1 (PLA2R1). Reactive in Human, Mouse, Rat. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
Phospholipase A2 Receptor 1 (PLA2R1), Antibody
Full Product Name
Polyclonal Antibody to Phospholipase A2 Receptor 1 (PLA2R1)
Product Gene Name
anti-PLA2R1 antibody
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.5mg/mL (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.
Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.
Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition
Matching Pairs
Unconjugated Antibody: PLA2R1 (MBS2017615)
FITC Conjugated Antibody: PLA2R1 (MBS2014684)
FITC Conjugated Antibody: PLA2R1 (MBS2014684)
Matching Pairs
Unconjugated Antibody: PLA2R1 (MBS2017615)
Immunogen: PLA2R1 (MBS2018771)
Immunogen: PLA2R1 (MBS2018771)
OMIM
U17033 mRNA
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Cross Reactivity
Mouse; Rat
Immunogen
Recombinant PLA2R1 (Tyr385~Cys643) expressed in E.coli ( MBS2018771 ).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-PLA2R1 antibody
Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP).
Application Notes for anti-PLA2R1 antibody
Western blotting: 0.01-2ug/mL;
Immunohistochemistry: 5-20ug/mL;
Immunocytochemistry: 5-20ug/mL;
Optimal working dilutions must be determined by end user
Immunohistochemistry: 5-20ug/mL;
Immunocytochemistry: 5-20ug/mL;
Optimal working dilutions must be determined by end user
Other Notes
Small volumes of anti-PLA2R1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for PLA2R1. It may not necessarily be applicable to this product.
NCBI Official Full Name
secretory phospholipase A2 receptor isoform 2
NCBI Official Synonym Full Names
phospholipase A2 receptor 1
NCBI Official Symbol
PLA2R1
NCBI Official Synonym Symbols
PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R
UniProt Protein Name
Secretory phospholipase A2 receptor
UniProt Synonym Protein Names
180 kDa secretory phospholipase A2 receptor; C-type lectin domain family 13 member C; M-type receptor
Protein Family
Secretory phospholipase A2 receptor
UniProt Gene Name
PLA2R1
UniProt Synonym Gene Names
CLEC13C; PLA2-R; PLA2R; Soluble PLA2-R; Soluble PLA2R
NCBI Protein Information
secretory phospholipase A2 receptor
NCBI Summary for PLA2R1
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Show more UniProt Comments for PLA2R1
PLA2R1: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 2q24.2
Cellular Component: cell surface; extracellular region; integral component of plasma membrane; plasma membrane; receptor complex
Molecular Function: carbohydrate binding; phospholipase binding; transmembrane receptor activity
Biological Process: cytokine production; positive regulation of DNA damage response, signal transduction by p53 class mediator; receptor-mediated endocytosis; signal transduction
Show more Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 2q24.2
Cellular Component: cell surface; extracellular region; integral component of plasma membrane; plasma membrane; receptor complex
Molecular Function: carbohydrate binding; phospholipase binding; transmembrane receptor activity
Biological Process: cytokine production; positive regulation of DNA damage response, signal transduction by p53 class mediator; receptor-mediated endocytosis; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-PLA2R1 antibody
| Reference Product | PubMed Publications |
|---|---|
| PLA2G10 antibody | >4 publications with PLA2R1 and PLA2G10 |
| PLA2G1B antibody | >3 publications with PLA2R1 and PLA2G1B |
| MYC antibody | >2 publications with PLA2R1 and MYC |
| PLA2G2A antibody | >2 publications with PLA2R1 and PLA2G2A |
| PLA2G2D antibody | >1 publications with PLA2R1 and PLA2G2D |
Pathways associated with anti-PLA2R1 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Phagosome Pathway antibodies | Phagosome Pathway Diagram |
| Phagosome Pathway antibodies | Phagosome Pathway Diagram |
| Tuberculosis Pathway antibodies | Tuberculosis Pathway Diagram |
| Tuberculosis Pathway antibodies | Tuberculosis Pathway Diagram |
Diseases associated with anti-PLA2R1 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Kidney Diseases Antibodies | >56 publications with PLA2R1 and Kidney Diseases |
| Proteinuria Antibodies | >16 publications with PLA2R1 and Proteinuria |
| Inflammation Antibodies | >15 publications with PLA2R1 and Inflammation |
| Necrosis Antibodies | >6 publications with PLA2R1 and Necrosis |
| Disease Models, Animal Antibodies | >5 publications with PLA2R1 and Disease Models, Animal |
| Cardiovascular Diseases Antibodies | >2 publications with PLA2R1 and Cardiovascular Diseases |
| Cell Transformation, Neoplastic Antibodies | >2 publications with PLA2R1 and Cell Transformation, Neoplastic |
| Adenocarcinoma Antibodies | >2 publications with PLA2R1 and Adenocarcinoma |
| Hyperplasia Antibodies | >1 publications with PLA2R1 and Hyperplasia |
| Fibrosis Antibodies | >1 publications with PLA2R1 and Fibrosis |
Organs/Tissues associated with anti-PLA2R1 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Kidney Antibodies | >31 publications with PLA2R1 and Kidney |
| Blood Antibodies | >26 publications with PLA2R1 and Blood |
| Muscle Antibodies | >6 publications with PLA2R1 and Muscle |
| Pancreas Antibodies | >5 publications with PLA2R1 and Pancreas |
| Lung Antibodies | >5 publications with PLA2R1 and Lung |
| Ovary Antibodies | >4 publications with PLA2R1 and Ovary |
| Vascular Antibodies | >3 publications with PLA2R1 and Vascular |
| Placenta Antibodies | >2 publications with PLA2R1 and Placenta |
| Brain Antibodies | >2 publications with PLA2R1 and Brain |
| Embryonic Tissue Antibodies | >2 publications with PLA2R1 and Embryonic Tissue |
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