251221 | Rabbit Anti-Collagen I Polyclonal Antibody Clinisciences

Rabbit Polyclonal Antibody

Cat. No.

251221

Unit

0.1 mg

Description

Type I collagen is present in connective tissue and bone where it makes up about 90% of the organic matrix. Defects in one or both alleles of the type I collagen gene causes "brittle bone disease" (osteogenesis imperfecta). Patients suffering from such defects have low levels of fully functional type I collagen resulting in fragile bones. Collagen Type 1 is synthesized with N-term and C-term propeptides. Product Cat. No. 251221 binds to the C-term propeptide region.

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Datasheet

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Isotype

Rabbit Ig

Applications

IHC

Species Reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Alternate Names

Collagen I; Collagen Type I; Collagen alpha-1(I) chain; Alpha-1 type I collagen; COL1A1

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Accession No.

P02452

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-terminal propeptide region of human collagen I.

Application Notes

E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Images

Collagen I staining in rat colon. Formalin-fixed paraffin-embedded rat colon tissue is stained with Collagen I Antibody (Cat. No. 251221) used at 1:200 dilution.

Collagen I Antibody (Cat. No. 251221) is used in Western blot at 1:200 to detect Collagen I in mouse muscle lysates.

Citations

Product Citations

[1]Kayumov FG et al. 2021. IOP Conf. Ser.: Earth Environ. Sci. 624 012030. [2] JS Choi et al. 2020. Tissue Engineering and Regenerative Medicine, Oct;17(5):651-658. PMID: 32676953.[3] Koudan EV et al. 2020. Biotechnol J. 15(5):e1900217. PMID 31995658. [4] KC Yang et al. 2015. School of Dental Technology, College of Oral Medicine, Taipei Medical University. Apr;40(4):E39-50. PMID: 26582651. [5] Lee S et al. 2015. Laryngoscope. 125(8): 1900-7. PMID 25891493. [6] Kim H et al. 2012. Chemistry and Material Science. Biotechnology and Bioprocess Engineering. 17(3):465-474. PMID# 21142100. [7] Wu C et al. 2012. Process Biochemistry. 47(6):922-928.

For research use only, not for diagnostic or therapeutic procedures.

Rabbit Anti-Collagen I Polyclonal Antibody

Referentie 251221

Merk : Abbiotec

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