Recombinant Bovine Bos d 4
Referentie DRA103-500ug
Formaat : 500ug
Merk : Novoprotein
Description Recombinant Bovine Bos d 4 is produced by our Mammalian expression system and the target gene encoding Glu20-Leu142 is expressed with a 6His tag at the C-terminus.
Accession P00711
Known As LALBA; LA;a-Lactalbumin; Alpha-lactalbumin; Lactose synthase B protein
Mol Mass 15 kDa
APMol Mass 13-20 kDa, reducing conditions
Formulation Description Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Purity-SDS-PAGE 
Greater than 95% as determined by reducing SDS-PAGE. (QC verified) Bioactivity Data 0
Storage - Reconstituted protein solution should be stored at ≤ -20°C.
- Stable for at least 24 months when stored as instructed.
Shipping The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Background Milk is one of the first food components introduced into the diet and therefore represents one of the most important food allergen sources in terms of frequency and severity of allergic manifestations. The symptoms of cow’s milk allergy are due to IgE-mediated activation of mast cells and basophils as well as to activation of allergen-specific T cells, and they comprise a plethora of gastrointestinal, skin, respiratory, and severe systemic manifestations such as death due to anaphylactic shock. Cow’s milk contains 25 different proteins, but only the whey proteins α-lactalbumin, β-lactoglobulin, BSA, and lactoferrin, as well as the four caseins, have been identified as allergens. a-Lactalbumin (LA) is the regulatory subunit of lactose synthase ,modulating the affinity of the catalytic component, for acceptor substrates through a reversible protein-protein interaction. it changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme.