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S-Nitroso-N-acetyl-DL-penicillamine [67776-06-1]

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Referentie NB-64-04317-25mg

Formaat : 25mg

Merk : Neo Biotech

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S-Nitroso-N-acetyl-DL-penicillamine

(Synonyms: SNAP) Copy Product Info

Synonyms: SNAP

Catalog No. T12808 Copy Product Info

Purity: 97.42%

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a stable inhibitor of platelet aggregation and a nitric oxide donor.

Cas No. 67776-06-1

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.42%

Product Introduction

Bioactivity

Description	S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a stable inhibitor of platelet aggregation and a nitric oxide donor.
In vitro	S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces approximately 80% toxicity under normoxic conditions by releasing nitric oxide (NO) after 6 hours [1]. It has a half-life of about 6 hours in isolated rat ventricular myocytes [3] and, at 100 μM for 30 minutes, causes a sustained decrease in basal pHi in these cells [3].
Synonyms	SNAP

Chemical Properties

Molecular Weight	220.25
Formula	C₇H₁₂N₂O₄S
Cas No.	67776-06-1
Smiles	CC(=O)NC(C(O)=O)C(C)(C)SN=O
Relative Density.	1.4261 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 3.45 mg/mL (15.66 mM), Sonication is recommended.

DMSO: 250 mg/mL (1135.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (22.7 mM), Sonication is recommended.

10% DMSO+90% Saline: 10 mg/mL (45.4 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5403 mL	22.7015 mL	45.4030 mL	227.0148 mL
5 mM	0.9081 mL	4.5403 mL	9.0806 mL	45.4030 mL
10 mM	0.4540 mL	2.2701 mL	4.5403 mL	22.7015 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.2270 mL	1.1351 mL	2.2701 mL	11.3507 mL
50 mM	0.0908 mL	0.4540 mL	0.9081 mL	4.5403 mL
100 mM	0.0454 mL	0.2270 mL	0.4540 mL	2.2701 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

S-Nitroso-N-acetyl-DL-penicillamineSNitrosoNacetylDLpenicillamineS Nitroso N acetyl DL penicillamineNOSynthaseNOSNO SynthaseNitric oxide synthasesInhibitorinhibit

Related Tags: S-Nitroso-N-acetyl-DL-penicillamine chemical structure | S-Nitroso-N-acetyl-DL-penicillamine in vitro | S-Nitroso-N-acetyl-DL-penicillamine formula | S-Nitroso-N-acetyl-DL-penicillamine molecular weight